Detailed information of TA system TA152280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 424652..425160
• Replicon: chromosome
• Accession: NZ_CP050136
• Organism: Kingella kingae strain ATCC 23332

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HBA47_RS02255
• Protein ID: WP_019389434.1
• Coordinates: 424900..425160 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HBA47_RS02250
• Protein ID: WP_019389435.1
• Coordinates: 424652..424909 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBA47_RS02235	419661..421391	-	1731	WP_060536984.1	PriCT-2 domain-containing protein	-
HBA47_RS02240	421388..423505	-	2118	WP_154699877.1	type IV secretory system conjugative DNA transfer family protein	-
HBA47_RS02245	423525..424586	-	1062	WP_019389436.1	P-type DNA transfer ATPase VirB11	-
HBA47_RS02250	424652..424909	+	258	WP_019389435.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
HBA47_RS02255	424900..425160	+	261	WP_019389434.1	Txe/YoeB family addiction module toxin	Toxin
HBA47_RS02260	425212..425460	-	249	WP_019389433.1	hypothetical protein	-
HBA47_RS02265	425500..426534	-	1035	WP_019389432.1	TrbI/VirB10 family protein	-
HBA47_RS02270	426547..427365	-	819	WP_019389431.1	TrbG/VirB9 family P-type conjugative transfer protein	-
HBA47_RS02275	427362..428063	-	702	WP_019389430.1	type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10457.92 Da
• Isoelectric Point: 5.6906

>T152280 WP_019389434.1 NZ_CP050136:424900-425160 [Kingella kingae]
MRLIFSDDAWQDYVYWQTADRKILKRINLLIQDIQREPFDGIGKPEPLRFNLAGFWSRRIDEEHRLVYAIEDESVLIVSC
RYHYQP

Nucleotide

• Length: 261 bp

>T152280 NZ_CP050136:424900-425160 [Kingella kingae]
ATGCGACTGATTTTTTCCGATGACGCATGGCAAGACTATGTGTATTGGCAAACCGCAGACCGAAAAATCTTAAAACGCAT
CAATCTGTTAATCCAAGACATTCAACGAGAACCGTTTGATGGCATCGGCAAACCGGAACCTTTGCGTTTCAATTTGGCTG
GATTTTGGTCAAGGCGCATTGATGAAGAACATCGCTTAGTCTATGCCATTGAAGATGAAAGTGTTTTAATCGTGTCTTGC
CGTTACCATTATCAACCTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9811.03 Da
• Isoelectric Point: 5.1111

>AT152280 WP_019389435.1 NZ_CP050136:424652-424909 [Kingella kingae]
MNTVTYSEVRQNLAKTMQEVVENHEPVLITRAKNEDCVLISLAHYRSLEETAYLLRSPANAAHLQRSIEQLRQNRGTEQE
LIECD

Nucleotide

• Length: 258 bp

>AT152280 NZ_CP050136:424652-424909 [Kingella kingae]
ATGAATACGGTAACTTATTCAGAAGTAAGACAAAATTTGGCAAAAACCATGCAAGAAGTCGTTGAAAATCATGAACCTGT
GTTGATTACACGCGCCAAAAATGAAGACTGTGTTTTGATTTCATTGGCGCATTACCGTTCTTTGGAGGAAACCGCTTATT
TGTTGCGTTCGCCAGCTAATGCCGCGCATTTGCAACGTTCCATTGAGCAGTTGCGCCAAAATCGCGGTACAGAACAGGAG
CTGATTGAATGCGACTGA