Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 220694..221340 Replicon chromosome
Accession NZ_CP050136
Organism Kingella kingae strain ATCC 23332

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag HBA47_RS01175 Protein ID WP_154699967.1
Coordinates 220933..221340 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag HBA47_RS01170 Protein ID WP_019389790.1
Coordinates 220694..220936 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA47_RS01150 216495..216731 + 237 WP_060537218.1 transposase family protein -
HBA47_RS01155 216759..217325 + 567 WP_060536953.1 ISAs1 family transposase -
HBA47_RS01160 217365..218498 - 1134 WP_019389792.1 hypothetical protein -
HBA47_RS01165 218520..220553 - 2034 WP_154699968.1 excinuclease ABC subunit B -
HBA47_RS01170 220694..220936 + 243 WP_019389790.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HBA47_RS01175 220933..221340 + 408 WP_154699967.1 type II toxin-antitoxin system VapC family toxin Toxin
HBA47_RS01180 221400..221897 - 498 WP_154699966.1 thiol peroxidase -
HBA47_RS01185 221991..222491 - 501 WP_019389787.1 hypothetical protein -
HBA47_RS01190 222579..223757 - 1179 WP_019389786.1 phosphoglycerate kinase -
HBA47_RS01195 223836..224468 - 633 WP_019389785.1 pyridoxamine 5'-phosphate oxidase -
HBA47_RS01200 224688..225938 + 1251 WP_019389784.1 glutamyl-tRNA reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 216759..232545 15786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin

SpoVT-AbrB domain

(6-40)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15219.41 Da        Isoelectric Point: 8.4436

>T152279 WP_154699967.1 NZ_CP050136:220933-221340 [Kingella kingae]
MMYLLDTNILIYIQKNNPSTVREKINNLPNSAQLVMSFVTYAELLKGAYGSQNSEKARANLNALTRIISVLPSHEAMPEH
YANWANQLKKQGKPIGNNDLWIAAHALAVSAVLVTHNTKEFSRINKLQLEDWAEE

Download         Length: 408 bp

>T152279 NZ_CP066093:276727-276981 [Streptococcus salivarius]
ATGTTACTCGCTTTCACTGAAGATGCATGGATGGATTATTGTTATTGGCAAAATCAGGATAGGAAGACACTTAAGCGAAT
CAATAAGCTGATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAACCAGAACCCTTGAAGTATGACTTTCAAG
GAGCTTGGTCTCGGCGAATTGATGCTGAAAATCGTTTGATTTATATGATTGATGGTAAGAGTGTCGCCTTTCTCTCTTTT
AAAGATCATTATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9278.53 Da        Isoelectric Point: 4.3193

>AT152279 WP_019389790.1 NZ_CP050136:220694-220936 [Kingella kingae]
MLTKVFQSGNSQAVRIPMNFRFDVDTVEIFRAENGDVILRLPKPQKRGDELFAILQQFDDDFIAIVEARDNEPPQEREVL

Download         Length: 243 bp

>AT152279 NZ_CP066093:276469-276723 [Streptococcus salivarius]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTAAAGGATTATATGAAAAAGGTTAATGATGAATTTGAACCTCT
AGCTGTGGTCAATAAAAATCCTGATGAAGATATTGTCGTAGTCTCAAAGAGTGAGTGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAGCAT
GCACTAAAGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References