Detailed information of TA system TA152278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1444087..1444637
• Replicon: chromosome
• Accession: NZ_CP050135
• Organism: Kingella kingae strain ATCC 23331

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HBA48_RS07475
• Protein ID: WP_003789642.1
• Coordinates: 1444087..1444356 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F5S5C2
• Locus tag: HBA48_RS07480
• Protein ID: WP_003785638.1
• Coordinates: 1444353..1444637 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBA48_RS07440	1439092..1439529	-	438	WP_026036193.1	DNA adenine methylase	-
HBA48_RS07445	1439550..1440146	-	597	WP_166503273.1	phage tail protein	-
HBA48_RS07450	1440159..1441499	-	1341	WP_166503274.1	phage tail protein	-
HBA48_RS07455	1441517..1442098	-	582	WP_166503275.1	phage tail protein I	-
HBA48_RS07460	1442095..1442991	-	897	WP_003789648.1	baseplate J/gp47 family protein	-
HBA48_RS07465	1442988..1443323	-	336	WP_003789646.1	GPW/gp25 family protein	-
HBA48_RS07470	1443320..1443928	-	609	WP_003789644.1	phage baseplate assembly protein V	-
HBA48_RS07475	1444087..1444356	-	270	WP_003789642.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HBA48_RS07480	1444353..1444637	-	285	WP_003785638.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HBA48_RS07485	1444832..1445566	-	735	WP_003789640.1	phage virion morphogenesis protein	-
HBA48_RS07490	1445570..1446001	-	432	WP_003789638.1	phage tail protein	-
HBA48_RS07495	1445988..1446206	-	219	WP_032828138.1	TraR/DksA C4-type zinc finger protein	-
HBA48_RS07500	1446190..1446432	-	243	WP_003789635.1	Rz1-like lysis system protein LysC	-
HBA48_RS07505	1446429..1446746	-	318	WP_003789633.1	hypothetical protein	-
HBA48_RS07510	1446743..1447258	-	516	WP_003789632.1	glycoside hydrolase family 108 protein	-
HBA48_RS07515	1447265..1447786	-	522	WP_164538194.1	ISAs1 family transposase	-
HBA48_RS07520	1447814..1448050	-	237	WP_003789355.1	transposase family protein	-
HBA48_RS07525	1448176..1448529	-	354	WP_003785632.1	phage holin family protein	-
HBA48_RS07530	1448592..1449449	+	858	WP_164538069.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1427475..1484700	57225

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-77)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10260.87 Da
• Isoelectric Point: 6.7090

>T152278 WP_003789642.1 NZ_CP050135:c1444356-1444087 [Kingella kingae]
MSREIIFQGQFKRDVKKQFLELATVEWAEVLTCLVNDLPLAEKYRDHALVNDKNGYRDCHIKPDLVLIYGSKENALILVR
LGSHSEIFG

Nucleotide

• Length: 270 bp

>T152278 NZ_CP066090:1344-1610 [Citrobacter koseri]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10648.21 Da
• Isoelectric Point: 7.0134

>AT152278 WP_003785638.1 NZ_CP050135:c1444637-1444353 [Kingella kingae]
MSAINFNIRMDKSLKERAFPVIESYGLTPAQAVKLFFNQIATTQTIPISFEHNVNRIPNAITRKAIEDAESEFETAKRYK
TVEEAIAAMQELAK

Nucleotide

• Length: 285 bp

>AT152278 NZ_CP066090:1136-1360 [Citrobacter koseri]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: F5S5C2