Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 280844..281490 Replicon chromosome
Accession NZ_CP050135
Organism Kingella kingae strain ATCC 23331

Toxin (Protein)


Gene name VapC1 Uniprot ID F5S4I4
Locus tag HBA48_RS01480 Protein ID WP_003785163.1
Coordinates 281083..281490 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID F5S4I3
Locus tag HBA48_RS01475 Protein ID WP_003785161.1
Coordinates 280844..281086 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA48_RS01455 276241..276984 + 744 WP_003791395.1 IS110 family transposase -
HBA48_RS01460 277087..277398 + 312 WP_003791394.1 transposase -
HBA48_RS01465 277768..278577 - 810 WP_003791390.1 hypothetical protein -
HBA48_RS01470 278664..280703 - 2040 WP_003791388.1 excinuclease ABC subunit B -
HBA48_RS01475 280844..281086 + 243 WP_003785161.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HBA48_RS01480 281083..281490 + 408 WP_003785163.1 type II toxin-antitoxin system VapC family toxin Toxin
HBA48_RS01485 281550..282047 - 498 WP_003785166.1 thiol peroxidase -
HBA48_RS01490 282141..282641 - 501 WP_003785168.1 hypothetical protein -
HBA48_RS01495 282732..283910 - 1179 WP_003785170.1 phosphoglycerate kinase -
HBA48_RS01500 283990..284622 - 633 WP_003791386.1 pyridoxamine 5'-phosphate oxidase -
HBA48_RS01505 284842..286092 + 1251 WP_003785176.1 glutamyl-tRNA reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-125)

Antitoxin

SpoVT-AbrB domain

(6-40)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15241.45 Da        Isoelectric Point: 6.8791

>T152277 WP_003785163.1 NZ_CP050135:281083-281490 [Kingella kingae]
MMYLLDTNILIYIQKNNPPTVREKINNLPNSAQLVMSFVTYAELLKGTYGSQNLEKAQANLNALTRIISVLPSHEAMPEH
YANWANQLKKQGKPIGNNDLWIAAHALAVGAVLVTHNTKEFSRINNLQLEDWVEE

Download         Length: 408 bp

>T152277 NZ_CP066089:3683833-3684240 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGGCCGCCTTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCATTTGTGGCTGGCGGCAGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9242.32 Da        Isoelectric Point: 4.1964

>AT152277 WP_003785161.1 NZ_CP050135:280844-281086 [Kingella kingae]
MLTKVFQSGNSQAVRIPMNFRFDVDTVEIFRTENGDVVLRSPKPQNRGDELFAILQQFDDDFIATVEARDNEPPQEREVL

Download         Length: 243 bp

>AT152277 NZ_CP066089:3683586-3683852 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGGGATGCAGAACTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5S4I4

Antitoxin

Source ID Structure
AlphaFold DB F5S4I3

References