152269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 975044..975633 Replicon chromosome
Accession NZ_CP050116
Organism Deinococcus radiodurans strain BNK-50

Toxin (Protein)


Gene name mazF Uniprot ID Q9RX98
Locus tag HAV23_RS04965 Protein ID WP_010887062.1
Coordinates 975280..975633 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q9RX99
Locus tag HAV23_RS04960 Protein ID WP_010887061.1
Coordinates 975044..975286 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAV23_RS04925 970056..970475 + 420 WP_010887054.1 DinB family protein -
HAV23_RS04930 970468..970839 + 372 Protein_958 inorganic pyrophosphatase -
HAV23_RS04935 970836..971519 + 684 WP_010887056.1 SDR family oxidoreductase -
HAV23_RS04940 971540..972502 + 963 WP_034349507.1 NAD(P)/FAD-dependent oxidoreductase -
HAV23_RS04945 972525..972704 + 180 WP_034349506.1 hypothetical protein -
HAV23_RS04950 972706..973335 + 630 WP_027479568.1 HAD family hydrolase -
HAV23_RS04955 973383..974864 - 1482 Protein_963 carboxylesterase/lipase family protein -
HAV23_RS04960 975044..975286 + 243 WP_010887061.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HAV23_RS04965 975280..975633 + 354 WP_010887062.1 endoribonuclease MazF Toxin
HAV23_RS04970 975686..975910 + 225 WP_162177573.1 hypothetical protein -
HAV23_RS04975 975907..976320 + 414 WP_010887064.1 type II toxin-antitoxin system VapC family toxin -
HAV23_RS04980 976317..978784 + 2468 Protein_968 ATP-dependent helicase HrpB -
HAV23_RS04985 978965..979189 - 225 WP_162177572.1 hypothetical protein -
HAV23_RS04990 979345..980121 - 777 WP_010887067.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12450.24 Da        Isoelectric Point: 7.3219

>T152269 WP_010887062.1 NZ_CP050116:975280-975633 [Deinococcus radiodurans]
MVSDYVPDAGHLVWLNFTPQAGHEQGGRRPALVLSPAAYNGVTGLMQACPVTSRAKGYPFEVTLPAHLGVSGVVLADHCR
SLDWRSRRAEQLAEAPADVLAEVRGKLGSLLGMSEKA

Download         Length: 354 bp

>T152269 NZ_CP066085:4472732-4472950 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8911.12 Da        Isoelectric Point: 4.3178

>AT152269 WP_010887061.1 NZ_CP050116:975044-975286 [Deinococcus radiodurans]
MTSQIQKWGNSLALRIPKALAQQVGLTQSSEVELLLQDGQIVIRPVPARQYDLAALLAEMTPENLHGETDWGALEGREEW

Download         Length: 243 bp

>AT152269 NZ_CP066085:4472331-4472705 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7D2M
PDB 7D2P
PDB 7DHP
PDB 7D2Q
PDB 7D28
PDB 7D2N

Antitoxin

Source ID Structure
AlphaFold DB Q9RX99

References