Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 520351..521021 Replicon plasmid pRL4b6
Accession NZ_CP050105
Organism Rhizobium leguminosarum bv. trifolii strain 4B

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HA460_RS31880 Protein ID WP_130748329.1
Coordinates 520351..520755 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HA460_RS31885 Protein ID WP_130748328.1
Coordinates 520752..521021 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA460_RS31855 515942..516475 + 534 WP_130653901.1 GNAT family N-acetyltransferase -
HA460_RS31860 517281..517841 - 561 WP_065277786.1 hypothetical protein -
HA460_RS31865 518052..518291 + 240 WP_130748331.1 hypothetical protein -
HA460_RS31870 518402..518658 + 257 Protein_485 hypothetical protein -
HA460_RS31875 518801..520051 + 1251 WP_130748330.1 hypothetical protein -
HA460_RS31880 520351..520755 - 405 WP_130748329.1 type II toxin-antitoxin system VapC family toxin Toxin
HA460_RS31885 520752..521021 - 270 WP_130748328.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HA460_RS31890 521246..521464 - 219 WP_003547964.1 hypothetical protein -
HA460_RS31895 521525..522370 - 846 WP_130748327.1 pirin family protein -
HA460_RS31900 522463..524223 - 1761 WP_130748326.1 MOSC domain-containing protein -
HA460_RS31905 524276..524833 - 558 WP_047617973.1 G/U mismatch-specific DNA glycosylase -
HA460_RS31910 524982..525464 + 483 WP_130748336.1 DMT family transporter -
HA460_RS31915 525461..525901 + 441 WP_047617979.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..693075 693075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin

SpoVT-AbrB domain

(18-53)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14214.64 Da        Isoelectric Point: 5.1421

>T152252 WP_130748329.1 NZ_CP050105:c520755-520351 [Rhizobium leguminosarum bv. trifolii]
VSRLYMLDTNIVSELARNPMGTITRRIAEVGPDAICVSIITASELRYGCAKKGSPKLLAQIEAILGSIPVLALDLPADAE
YGGIRAELEAAGKPIGPNDLFIAAHASALGAVLVTANMGEFMRIRALQVENWLI

Download         Length: 405 bp

>T152252 NZ_CP066078:322747-323007 [Rothia kristinae]
GTGAAGACGATGACGTACACGGAGTCTCGGGCGCGCTATGCCGAGGTGCTGGACGGCGTGGTGCAGGACCGGGAGGAGGT
GGTGATCACCCGCAGCGGTCACGACCCGGTGGTGATCCTCTCCCTGGCGGAGTATGAGTCGCTGAAGGAGACGGCGCACC
TGCTGCGCTCCCCCGCCAATGCCCGTCGGCTGCTGGATGCGATGCAGCGTCTGGAGGCGGGACAGGGCCAGCGCCACGAG
CTCGTGGACCCCGATGCCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10180.62 Da        Isoelectric Point: 4.8728

>AT152252 WP_130748328.1 NZ_CP050105:c521021-520752 [Rhizobium leguminosarum bv. trifolii]
VVNSRHQEPIPQREAKLFRNNKSQAVRIPADFELPGDRVMIHRDGDRLIIEPVHRKNLLEVLAGLEPLGPEDQFPDVDDT
LLPVKEIDL

Download         Length: 270 bp

>AT152252 NZ_CP066078:323000-323269 [Rothia kristinae]
ATGCCTGACCTGCTGCTGACCTGGGACCCTGAGGCCTGGGAGGACTACCTGTGGTGGCAGCGCCAGGATCGCGCCGTGCT
GCGTCGGATCAACACGCTGATCCGGGACATCCAGCGCCACGGGAATGAGGGCATCGGCAAACCGGAGCCGCTGCGTCATG
ACTTCGCCGGGTATTGGTCCCGCCGGATCACCGCGGAGCACCGACTGGTCTATCGGCTCACCGACCGTCAGGTGCTCATC
GCCGCGTGCCGCTACCACTACGGTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References