152244

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 237589..238121 Replicon chromosome
Accession NZ_CP050097
Organism Rhizobium leguminosarum bv. trifolii strain 9B

Toxin (Protein)


Gene name parE Uniprot ID A0A6G8VGK8
Locus tag HA461_RS01075 Protein ID WP_033181870.1
Coordinates 237831..238121 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6G8VFB5
Locus tag HA461_RS01070 Protein ID WP_033182117.1
Coordinates 237589..237834 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA461_RS01045 233135..234088 + 954 WP_166470320.1 ABC transporter substrate-binding protein -
HA461_RS01050 234220..235098 + 879 WP_017989717.1 ABC transporter permease -
HA461_RS01055 235095..235889 + 795 WP_166470321.1 ABC transporter ATP-binding protein -
HA461_RS01060 235924..236565 - 642 WP_033181872.1 LysE family translocator -
HA461_RS01065 236651..237502 - 852 WP_033181871.1 SDR family NAD(P)-dependent oxidoreductase -
HA461_RS01070 237589..237834 + 246 WP_033182117.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HA461_RS01075 237831..238121 + 291 WP_033181870.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HA461_RS01080 238227..239450 + 1224 WP_029870914.1 argininosuccinate synthase -
HA461_RS01085 239767..240777 - 1011 WP_166470322.1 DUF3095 family protein -
HA461_RS01090 240883..241278 - 396 WP_012759338.1 Ohr family peroxiredoxin -
HA461_RS01095 241595..242902 + 1308 WP_208026269.1 epoxide hydrolase N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(2-78)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10920.62 Da        Isoelectric Point: 8.8808

>T152244 WP_033181870.1 NZ_CP050097:237831-238121 [Rhizobium leguminosarum bv. trifolii]
MKALVLSPAAVDDIDRIYDYTEEKWGQGQAEDYIVALRDDCQALAAQTKRGRKIIGLRSGYTALAFRSHFVIYAETEKVL
TVIRILHRRMNIAAHL

Download         Length: 291 bp

>T152244 NZ_CP066072:31050-31328 [Providencia stuartii]
ATGGAGTTAAAGTGGACGAGCAAAGCATTATCGGATCTCTCTCGAGTCTATGATTTTTTGGCCTTCTCAAACACAGCCGC
TGCAGCGCGTGTTGTGCAAACATTGACGCAAGCACCGGTGTCATTGTTGGTAAATAATCCCCGTATGGGTGAACAATTGT
TCCAATTTATGCCACATGAAGTTCGTCGAGTTGTGGTGGCGAATTATGAGGTACGCTATGAAATCATTGACTCGACAATC
TATATTTTGCGGATATGGCACACTCGGGAAGATCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8937.02 Da        Isoelectric Point: 4.6652

>AT152244 WP_033182117.1 NZ_CP050097:237589-237834 [Rhizobium leguminosarum bv. trifolii]
VAKVVSIRIDDHMEEFIGNQLDQGAYGSADEVIDAGLRLLQREAELAAIEAAIIEGEKSGKPRPFDFDAFIEGKRARHGR
Q

Download         Length: 246 bp

>AT152244 NZ_CP066072:30769-31050 [Providencia stuartii]
ATGAAAAACAGTTCGGTACAAAATTCGACAAAAGTGCTAACGGCACATGTGCCCTTAGCGATGGCAGATAAAGTCGATGA
AATCGCGGCTCGCCTCGAACGTTCTCGAGGATGGGTCATGAAACAAGCGCTGTCAACGTGGATAGCTCAGGAGGAGATGC
GGGATACATTGACACGAGAGGCGCTATCAGATGTTGAATCTGGCCGCGTTATTGATCATCAGTTCGTGCAAGATTGGGCC
GCGAGTTTGAGTTCTGACCAGCCATTACCGGTGCCTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G8VGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A6G8VFB5

References