Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_26
Location 2973339..2973941 Replicon chromosome
Accession NZ_CP050091
Organism Rhizobium leguminosarum bv. trifolii strain 22B

Toxin (Protein)


Gene name relE Uniprot ID A0A154IHS8
Locus tag HA462_RS14830 Protein ID WP_011650400.1
Coordinates 2973696..2973941 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q1MLN9
Locus tag HA462_RS14825 Protein ID WP_011650401.1
Coordinates 2973339..2973686 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA462_RS14805 2969034..2969609 + 576 WP_011650405.1 hypothetical protein -
HA462_RS14810 2969700..2971415 + 1716 WP_166478116.1 type I secretion system permease/ATPase -
HA462_RS14815 2971430..2972890 + 1461 WP_011650403.1 HlyD family type I secretion periplasmic adaptor subunit -
HA462_RS14820 2972898..2973176 + 279 WP_028740383.1 transposase -
HA462_RS14825 2973339..2973686 - 348 WP_011650401.1 helix-turn-helix transcriptional regulator Antitoxin
HA462_RS14830 2973696..2973941 - 246 WP_011650400.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
HA462_RS14840 2974345..2974557 - 213 WP_011650399.1 DNA gyrase inhibitor YacG -
HA462_RS14845 2974687..2975307 - 621 WP_003545339.1 Maf-like protein -
HA462_RS14850 2975366..2975584 - 219 WP_003545338.1 translation initiation factor IF-1 -
HA462_RS14855 2975708..2976193 - 486 WP_028740385.1 arsenate reductase -
HA462_RS14860 2976190..2976663 - 474 WP_011650397.1 UPF0262 family protein -
HA462_RS14865 2976668..2977966 - 1299 WP_028740386.1 histidinol dehydrogenase -
HA462_RS14870 2978022..2978453 - 432 WP_166478117.1 DUF2948 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(63-113)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9050.61 Da        Isoelectric Point: 10.7504

>T152239 WP_011650400.1 NZ_CP050091:c2973941-2973696 [Rhizobium leguminosarum bv. trifolii]
MKKIAYSKAATKALRKMQPKRAAAIVARVEAFANGESVDLKKLQGSEFFRIRVGQDRVIIDDQTMQVLVIKAGPRGDIYN
E

Download         Length: 246 bp

>T152239 NZ_CP066069:c1214963-1214118 [Streptococcus dysgalactiae]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAACTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTCCAAACCATCTATTCACGAAACTTCTTGAACAGCAGAAG
CAAAGACTTTTACGATGTTTATATTCTTTCAAAATTGAAGAAAAAAGATATTGATTTCAATCAGTTAAAAAATGCTTGCC
AAAGAACTTTTTCCTATCGCGAAACTGAGCTCGATTTCGAAAAAATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGTTATACAAAAGGAATTTCACTTGCAAATGTGCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12504.08 Da        Isoelectric Point: 4.3175

>AT152239 WP_011650401.1 NZ_CP050091:c2973686-2973339 [Rhizobium leguminosarum bv. trifolii]
MGEIQKLTIDGKGYVLLSEDDYQDLVDISEARAAKARIGAGEETWPEDVVKALIAGEDPVRVFRKHRGMSIKELAEKSGL
SQPYLSEIETGKKEGSLDALRSIASALDVDLDDVA

Download         Length: 348 bp

>AT152239 NZ_CP066069:c1215550-1214960 [Streptococcus dysgalactiae]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGCATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAACATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A154IHS8

Antitoxin

Source ID Structure
AlphaFold DB Q1MLN9

References