Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 478348..479150 Replicon plasmid pRL23b7
Accession NZ_CP050086
Organism Rhizobium leguminosarum bv. trifolii strain 23B

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A444IGY5
Locus tag HA463_RS26935 Protein ID WP_018245608.1
Coordinates 478348..478875 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A7Y3SJF5
Locus tag HA463_RS26940 Protein ID WP_018245607.1
Coordinates 478872..479150 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA463_RS26920 473646..474770 - 1125 WP_018245611.1 DNA repair exonuclease -
HA463_RS26925 475060..476451 - 1392 WP_026188694.1 aldehyde dehydrogenase family protein -
HA463_RS26930 476453..478099 - 1647 WP_018245609.1 acetolactate synthase large subunit -
HA463_RS26935 478348..478875 - 528 WP_018245608.1 GNAT family N-acetyltransferase Toxin
HA463_RS26940 478872..479150 - 279 WP_018245607.1 DUF1778 domain-containing protein Antitoxin
HA463_RS26945 479305..480183 - 879 WP_026188693.1 hypothetical protein -
HA463_RS26950 480507..482621 - 2115 WP_018245605.1 carboxy terminal-processing peptidase -
HA463_RS26955 482769..483248 - 480 WP_020493431.1 MEKHLA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1212571 1212571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(12-87)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18780.78 Da        Isoelectric Point: 9.5510

>T152234 WP_018245608.1 NZ_CP050086:c478875-478348 [Rhizobium leguminosarum bv. trifolii]
VTLPVWHEEPIAKSHDRASFDCGDAAMNEFIRRFARQSHEQNAAKTFCAIDKAHPDRILGFYTVAPSAVTHEAVPPKMTR
GLARHEVAGFKLARLATDIKVAGKGLGGQLIAAAALRCLRLASEGGGILLIIDAKSERAAHWYASYGAEPLQGKPLTLVM
PLATFAADLKAKGLL

Download         Length: 528 bp

>T152234 NZ_CP066062:c1829732-1829271 [Staphylococcus pettenkoferi]
ATGGGGTTATATGAAAAAATGTTAATAGAACATGATTATATAGAAGTTAGAGAAACAAATGTTATGCCTAATGACCTACA
CGGTCTATGGTTAGGCGATTTAATTTTAATTAAGCGAAACTTATCAGAAATACGAAAAGCCGAAGTCTTATACGAAGAAC
TCGCACATCATAAACTTACATACGGTAACATATTAGACCAATCTAAATGGATTAACCGCAAGTTTGAAAATTATGCTAAA
CGTCACGGATACGAGGCTGCACTACCCTTACGTATTATCGTTGAGGCACATCACTACGGTGTAAGTAACTTATATGAATT
AGCTGAATATGTTCAATTAAGTGAAGAATATATAGTAGAAATATTGAAACATTACAAAAATAAATATGGTATTGGAACTC
ACTACGGAGAATACCTAATTACATTTGATCCGTTAAGAGTTTTTAAATATATAGAAATATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10222.91 Da        Isoelectric Point: 9.8602

>AT152234 WP_018245607.1 NZ_CP050086:c479150-478872 [Rhizobium leguminosarum bv. trifolii]
MPRTADNKSERYQLRIPPKQKAMIARAAALSNKDMADFILDKIVPEAEAVIQAAEVETVSSRDFIRILDLLERPPKPNAR
LRAAISALPDAL

Download         Length: 279 bp

>AT152234 NZ_CP066062:c1830073-1829744 [Staphylococcus pettenkoferi]
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTAGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAACTTAACTAGAGAATTTCCGTTAAATCGTACAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATACTTACTTGGTTTTGACAAAAGTGAGCAACAAGATGAACAACCAAAACAT
CGTGCAGCACATCTTGAAGGTGAATTGACAGATGAAGAATGGCAACGTGTGCTAGATTATGCAGATTATATAAGAAGCAA
ACGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444IGY5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3SJF5

References