Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1846342..1846954 | Replicon | chromosome |
| Accession | NZ_CP050078 | ||
| Organism | Citrobacter koseri strain NJ | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | D2TUP9 |
| Locus tag | NCK_RS08780 | Protein ID | WP_012906750.1 |
| Coordinates | 1846775..1846954 (-) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | NCK_RS08775 | Protein ID | WP_047463070.1 |
| Coordinates | 1846342..1846752 (-) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NCK_RS08730 (1841626) | 1841626..1841838 | + | 213 | WP_114647479.1 | cold shock domain-containing protein | - |
| NCK_RS08735 (1841849) | 1841849..1842037 | + | 189 | WP_129984237.1 | cold-shock protein | - |
| NCK_RS08740 (1842112) | 1842112..1842339 | + | 228 | WP_219936925.1 | hypothetical protein | - |
| NCK_RS08755 (1843767) | 1843767..1843940 | + | 174 | WP_114647475.1 | addiction module toxin, GnsA/GnsB family | - |
| NCK_RS08760 (1844175) | 1844175..1844630 | + | 456 | WP_258237902.1 | DUF1441 family protein | - |
| NCK_RS08765 (1844630) | 1844630..1845208 | + | 579 | WP_200096364.1 | tail fiber assembly protein | - |
| NCK_RS08770 (1845301) | 1845301..1846284 | - | 984 | WP_058667560.1 | glycosyltransferase | - |
| NCK_RS08775 (1846342) | 1846342..1846752 | - | 411 | WP_047463070.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| NCK_RS08780 (1846775) | 1846775..1846954 | - | 180 | WP_012906750.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| NCK_RS08785 (1847450) | 1847450..1847863 | + | 414 | WP_219937110.1 | lipoprotein YedD | - |
| NCK_RS08790 (1847944) | 1847944..1849431 | - | 1488 | WP_115609214.1 | alpha-amylase | - |
| NCK_RS08795 (1849499) | 1849499..1849861 | - | 363 | WP_012131914.1 | flagella biosynthesis regulatory protein FliT | - |
| NCK_RS08800 (1849861) | 1849861..1850271 | - | 411 | WP_012131915.1 | flagellar export chaperone FliS | - |
| NCK_RS08805 (1850281) | 1850281..1851708 | - | 1428 | WP_058669294.1 | flagellar filament capping protein FliD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1833077..1846954 | 13877 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6644.85 Da Isoelectric Point: 10.9132
>T152212 WP_012906750.1 NZ_CP050078:c1846954-1846775 [Citrobacter koseri]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
Download Length: 180 bp
>T152212 NZ_CP066042:c2288308-2288135 [Staphylococcus saccharolyticus]
ATGTCGAATAAAAAGAATTCTAAATTAAATTATCATGAAGAAGAAAATGCAATGGTAACAGATTTAGATGATTTAAAAGA
ATTAGGTAAAGAGATGGAACATATTTCTGAGAAGAATGATGAAGATAAAGTTAATCAATCTCATGATGAGATTTGTTCTG
ATAAAACTAACTAA
ATGTCGAATAAAAAGAATTCTAAATTAAATTATCATGAAGAAGAAAATGCAATGGTAACAGATTTAGATGATTTAAAAGA
ATTAGGTAAAGAGATGGAACATATTTCTGAGAAGAATGATGAAGATAAAGTTAATCAATCTCATGATGAGATTTGTTCTG
ATAAAACTAACTAA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14887.79 Da Isoelectric Point: 4.3006
>AT152212 WP_047463070.1 NZ_CP050078:c1846752-1846342 [Citrobacter koseri]
MLYPIAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESVREAIDAHIELLVEDGEAVPEATSVENWLDDPDYAGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
MLYPIAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESVREAIDAHIELLVEDGEAVPEATSVENWLDDPDYAGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
Download Length: 411 bp
>AT152212 NZ_CP066042:c2288932-2288333 [Staphylococcus saccharolyticus]
ATGGCAATGAACTTTAAAGTATTTGATAATAATGATAGAGTAGCAGAATACGCTGCTGATATTATTCGCAAACAATTTAA
TAATAATCCTACGACAATTGCAGGGTTTCATTTAGATAAAGAACATGCACCTGTTCTTGATGAACTTAAAAAAAATGTCG
ACTGCCATGCTGTTGATTTCAGTCAAATTAACATTTTAGATTATGATAATAATCGTTCTTACTATGAAACATTAGGAGTT
CCAGAAGGTCAAGTGTATTCAATTTCTTATGATCAAGATGCAATTGGATTTATTTCAGACAAGATGAAAACGAAAGAAAA
TAAAGGTAAACTTATTTTACAAGTATTATCAATTGATGAAAATGGAAAATTAGACGTTAATGTACGCCAAGGGTTGATGG
AAGCTAGAGAAATTTTCCTTATCATTACAGGCAGTCAAAAACGTGATGTTGTTGAAAAATTATATCGCGAGAATGGCAAA
TCTAGTTATGAACCAGCTGATTTAAAAGCACACCGTATGGTCAATGTTATTTTAGATAAAGAATCAGCAGAAGGTTTACC
TGAAGATGTTAAAGAGTACTTCACAGCGCGTTTTGCATAA
ATGGCAATGAACTTTAAAGTATTTGATAATAATGATAGAGTAGCAGAATACGCTGCTGATATTATTCGCAAACAATTTAA
TAATAATCCTACGACAATTGCAGGGTTTCATTTAGATAAAGAACATGCACCTGTTCTTGATGAACTTAAAAAAAATGTCG
ACTGCCATGCTGTTGATTTCAGTCAAATTAACATTTTAGATTATGATAATAATCGTTCTTACTATGAAACATTAGGAGTT
CCAGAAGGTCAAGTGTATTCAATTTCTTATGATCAAGATGCAATTGGATTTATTTCAGACAAGATGAAAACGAAAGAAAA
TAAAGGTAAACTTATTTTACAAGTATTATCAATTGATGAAAATGGAAAATTAGACGTTAATGTACGCCAAGGGTTGATGG
AAGCTAGAGAAATTTTCCTTATCATTACAGGCAGTCAAAAACGTGATGTTGTTGAAAAATTATATCGCGAGAATGGCAAA
TCTAGTTATGAACCAGCTGATTTAAAAGCACACCGTATGGTCAATGTTATTTTAGATAAAGAATCAGCAGAAGGTTTACC
TGAAGATGTTAAAGAGTACTTCACAGCGCGTTTTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|