Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4136515..4137268 Replicon chromosome
Accession NZ_CP050073
Organism Enterobacter kobei strain 070

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag HA514_RS19945 Protein ID WP_025799003.1
Coordinates 4136515..4136892 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag HA514_RS19950 Protein ID WP_072269511.1
Coordinates 4136942..4137268 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA514_RS19915 4131689..4133533 + 1845 WP_014885285.1 RNA polymerase sigma factor RpoD -
HA514_RS19920 4134058..4134564 - 507 WP_121527328.1 G/U mismatch-specific DNA glycosylase -
HA514_RS19930 4134868..4135713 - 846 WP_049016442.1 DUF4942 domain-containing protein -
HA514_RS19935 4135795..4135998 - 204 WP_025799007.1 DUF957 domain-containing protein -
HA514_RS19940 4136027..4136518 - 492 WP_045888216.1 hypothetical protein -
HA514_RS19945 4136515..4136892 - 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
HA514_RS19950 4136942..4137268 - 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HA514_RS19955 4137325..4137546 - 222 WP_045888217.1 DUF987 domain-containing protein -
HA514_RS19960 4137560..4138039 - 480 WP_025798999.1 DNA repair protein RadC -
HA514_RS19965 4138051..4138482 - 432 WP_088903392.1 antirestriction protein -
HA514_RS19970 4138705..4141857 - 3153 WP_049015608.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T152206 WP_025799003.1 NZ_CP050073:c4136892-4136515 [Enterobacter kobei]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T152206 NZ_CP066040:633162-633461 [Burkholderia ambifaria]
ATGCCGATTGAGGCGCGTCTGGTGCGGCTGACGCCGCTGGCCGAGGCCGATCTCGAGGACATCTGGACCTACACCTTCGA
ACGCTGGTCGCTTGAGCAGGCCGAGCACTATGTGGGCGAGCTCGCCTCGGCGTTCGAGCGTCTCGCGCGGCGCGAGTGGA
GAGGGCGACCGAGTCGTGCGGGCAACGGCTATTGGCGCTACATGGTCGGTTCCCACGTGGTGTTCTATCGGGAAACGGCC
GACAGCCTTGACGTGATTCGGGTATTGCATCAACGCATGGACGTGGACCGGCACCTGTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT152206 WP_072269511.1 NZ_CP050073:c4137268-4136942 [Enterobacter kobei]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT152206 NZ_CP066040:632927-633172 [Burkholderia ambifaria]
ATGGCACGGAACACTTCAATCTCGCTGGGAGACCACCTCGCTCAGTTTGTCGACACGCAGGTCGCATCCGGTCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGCTGCGCCTGCTCGAAACGCAGGAAACCGAGTTGCGGGCCCTGCAGGAGGCCT
TGAAGGCCGGCGAGGCCTCGGGCGAGCCGACTGCCTTTGACAGCCAGGCGTTCTTGGAGCGGATGCGGAAAAAGCATGCC
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References