Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3918770..3919427 Replicon chromosome
Accession NZ_CP050073
Organism Enterobacter kobei strain 070

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag HA514_RS18900 Protein ID WP_014885136.1
Coordinates 3918770..3919180 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag HA514_RS18905 Protein ID WP_010435322.1
Coordinates 3919161..3919427 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA514_RS18880 3914764..3916497 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
HA514_RS18885 3916503..3917216 - 714 WP_121528248.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HA514_RS18890 3917245..3918141 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
HA514_RS18895 3918243..3918764 + 522 WP_014885135.1 flavodoxin FldB -
HA514_RS18900 3918770..3919180 - 411 WP_014885136.1 protein YgfX Toxin
HA514_RS18905 3919161..3919427 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
HA514_RS18910 3919722..3920702 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
HA514_RS18915 3920787..3921446 - 660 WP_023331242.1 hemolysin III family protein -
HA514_RS18920 3921713..3922444 + 732 WP_121528331.1 MurR/RpiR family transcriptional regulator -
HA514_RS18925 3922561..3923994 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T152204 WP_014885136.1 NZ_CP050073:c3919180-3918770 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T152204 NZ_CP066034:58534-58686 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT152204 WP_010435322.1 NZ_CP050073:c3919427-3919161 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT152204 NZ_CP066034:c58484-58422 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References