Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 379872..380625 Replicon plasmid p35
Accession NZ_CP050068
Organism Klebsiella aerogenes strain 035

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HA513_RS25280 Protein ID WP_135683935.1
Coordinates 380248..380625 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HA513_RS25275 Protein ID WP_162838704.1
Coordinates 379872..380198 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA513_RS25215 374930..375196 + 267 WP_009652486.1 hypothetical protein -
HA513_RS25220 375209..375520 + 312 WP_009652410.1 hypothetical protein -
HA513_RS25225 375567..376037 + 471 WP_009652431.1 hypothetical protein -
HA513_RS25230 376086..376598 + 513 WP_009652395.1 DUF4234 domain-containing protein -
HA513_RS25235 376681..376902 + 222 WP_009652443.1 hypothetical protein -
HA513_RS25240 376958..377191 + 234 WP_009652474.1 DUF905 domain-containing protein -
HA513_RS25245 377295..378113 + 819 WP_009652424.1 DUF945 domain-containing protein -
HA513_RS25250 378113..378367 + 255 WP_009652519.1 hypothetical protein -
HA513_RS25255 378396..378857 + 462 WP_045890390.1 antirestriction protein -
HA513_RS25260 378868..379086 + 219 WP_009652503.1 hypothetical protein -
HA513_RS25265 379098..379580 + 483 WP_052238324.1 DNA repair protein RadC -
HA513_RS25270 379594..379815 + 222 WP_009652392.1 DUF987 domain-containing protein -
HA513_RS25275 379872..380198 + 327 WP_162838704.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HA513_RS25280 380248..380625 + 378 WP_135683935.1 TA system toxin CbtA family protein Toxin
HA513_RS25285 380622..381113 + 492 WP_009652438.1 hypothetical protein -
HA513_RS25290 381143..381346 + 204 WP_009652505.1 DUF957 domain-containing protein -
HA513_RS25295 381427..382272 + 846 Protein_397 DUF4942 domain-containing protein -
HA513_RS25300 382496..383503 + 1008 Protein_398 hypothetical protein -
HA513_RS25305 383506..383979 + 474 WP_009652494.1 ribbon-helix-helix protein, CopG family -
HA513_RS25310 384299..384937 + 639 WP_009652437.1 VWA domain-containing protein -
HA513_RS25315 384962..385603 + 642 WP_009652489.1 TerD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..397663 397663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.22 Da        Isoelectric Point: 9.5224

>T152189 WP_135683935.1 NZ_CP050068:380248-380625 [Klebsiella aerogenes]
MQTQPVPPKREVSPRPSPVAIWLRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T152189 NZ_CP066032:2193583-2193990 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTTGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12079.85 Da        Isoelectric Point: 6.6283

>AT152189 WP_162838704.1 NZ_CP050068:379872-380198 [Klebsiella aerogenes]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 327 bp

>AT152189 NZ_CP066032:2193336-2193602 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References