Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3608816..3609435 Replicon chromosome
Accession NZ_CP050067
Organism Klebsiella aerogenes strain 035

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag HA513_RS17550 Protein ID WP_015367918.1
Coordinates 3609217..3609435 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag HA513_RS17545 Protein ID WP_015367917.1
Coordinates 3608816..3609190 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA513_RS17535 3603975..3605174 + 1200 WP_047038885.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HA513_RS17540 3605197..3608343 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
HA513_RS17545 3608816..3609190 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
HA513_RS17550 3609217..3609435 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
HA513_RS17555 3609567..3610130 + 564 WP_020079452.1 maltose O-acetyltransferase -
HA513_RS17560 3610256..3610720 + 465 WP_042893755.1 YlaC family protein -
HA513_RS17565 3610695..3612149 - 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
HA513_RS17570 3612252..3612962 + 711 WP_015704607.1 GNAT family N-acetyltransferase -
HA513_RS17575 3612959..3613099 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HA513_RS17580 3613102..3613362 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T152185 WP_015367918.1 NZ_CP050067:3609217-3609435 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T152185 NZ_CP066032:c1066959-1066648 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT152185 WP_015367917.1 NZ_CP050067:3608816-3609190 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT152185 NZ_CP066032:c1066647-1066357 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References