Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 272910..273541 Replicon chromosome
Accession NZ_CP050067
Organism Klebsiella aerogenes strain 035

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag HA513_RS01265 Protein ID WP_015703741.1
Coordinates 272910..273185 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag HA513_RS01270 Protein ID WP_015703740.1
Coordinates 273182..273541 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA513_RS01245 268139..268474 + 336 WP_015703743.1 universal stress protein UspB -
HA513_RS01250 268539..270035 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
HA513_RS01255 270266..271459 + 1194 WP_058676350.1 NAD(P)/FAD-dependent oxidoreductase -
HA513_RS01260 271500..272513 - 1014 WP_058676351.1 magnesium transporter -
HA513_RS01265 272910..273185 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
HA513_RS01270 273182..273541 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HA513_RS01275 273569..273970 - 402 WP_058676352.1 nickel-responsive transcriptional regulator NikR -
HA513_RS01280 273958..274749 - 792 WP_166479548.1 nickel import ATP-binding protein NikE -
HA513_RS01285 274746..275510 - 765 WP_047466602.1 nickel import ATP-binding protein NikD -
HA513_RS01290 275510..276343 - 834 WP_032713130.1 nickel ABC transporter permease subunit NikC -
HA513_RS01295 276340..277284 - 945 WP_015703735.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T152173 WP_015703741.1 NZ_CP050067:272910-273185 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T152173 NZ_CP066019:2612293-2612469 [Cupriavidus necator]
GTGAAGCGGAGTGAATTCCGGCGATGGCTCGCCGGACAGGGCGCCACCTTCAGTGAAGGCGCGAAGCATGTGAGGGTGTA
TCTCAATGGCAGGAAGACCACGCTGCCACGGCATCCCAGCCACGAGATCCGGGAGGGGTTGCGCAAGGCGATTCTCAAGC
AACTCGGCCTGTCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT152173 WP_015703740.1 NZ_CP050067:273182-273541 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT152173 NZ_CP066019:2612520-2612936 [Cupriavidus necator]
ATGCTGCGTTTCCCTGCCAACATCGTCCCGGACGACGGTGGCTTTGCTGTGTCGTTTCCCGATATCCCCGAAGCCCTGAC
CAGCGGCGACACCATCGAGCAGGCCCGCGAAATGGCCGCCGATGCGCTCGCCACGGCCATGGAATTCTATTTCGAAGATG
GCCGCCCGGTGCCACTGCCGTCGAAGGCAAAACGCGGCCAGCATCTGGTTGAACTGCCGGCCAGCGTGTCGGCGAAGGTG
CTCCTGCTTAACGAGATGATCGCGCAGGGCGTGACGCAGGCGGAACTGGCGCGCCGGCTGAATACGCGCAAGCAAGAGGT
GCAACGTATCGTCAACCTGGACCATGCGACCAAGATCGATACGATCGAGGCTGCATTCCGGGCGCTGGGGAAGCGGCTGG
AACTGACGGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References