Detailed information of TA system TA152170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 3237128..3237720
• Replicon: chromosome
• Accession: NZ_CP050066
• Organism: Bradyrhizobium symbiodeficiens strain 101S1MB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HAV00_RS15090
• Protein ID: WP_094976673.1
• Coordinates: 3237532..3237720 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HAV00_RS15085
• Protein ID: WP_094976672.1
• Coordinates: 3237128..3237526 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAV00_RS15065	3233089..3233508	-	420	WP_094976668.1	acyl-CoA thioesterase	-
HAV00_RS15070	3233521..3234282	-	762	WP_094976669.1	SDR family NAD(P)-dependent oxidoreductase	-
HAV00_RS15075	3234310..3236193	-	1884	WP_166468025.1	feruloyl-CoA synthase	-
HAV00_RS15080	3236190..3236999	-	810	WP_094976671.1	crotonase/enoyl-CoA hydratase family protein	-
HAV00_RS15085	3237128..3237526	-	399	WP_094976672.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HAV00_RS15090	3237532..3237720	-	189	WP_094976673.1	type II toxin-antitoxin system HicA family toxin	Toxin
HAV00_RS15095	3237765..3238226	-	462	WP_166468026.1	DUF3237 domain-containing protein	-
HAV00_RS15100	3238239..3239558	-	1320	WP_094976675.1	TRAP transporter permease	-
HAV00_RS15105	3239561..3240070	-	510	WP_094976676.1	TRAP transporter small permease	-
HAV00_RS15110	3240274..3241290	-	1017	WP_094976677.1	TRAP transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7009.08 Da
• Isoelectric Point: 11.9537

>T152170 WP_094976673.1 NZ_CP050066:c3237720-3237532 [Bradyrhizobium symbiodeficiens]
MNSRDIISALHRDGWVQVAQKGSHVQFRHPTKKGRVTVPHPKRDIALGTLKSIEQQSGLQLR

Nucleotide

• Length: 189 bp

>T152170 NZ_CP066019:1346239-1346712 [Cupriavidus necator]
GTGAGGCCAGCCTGGCGGATCGCGACCGACACCCCAGACTACACCGCCGACGACGCCAGCGGCGCCGGCGCCAAGGCCAC
CGGCGGGCGCTGGAACCGGCAGGGCACGCCCTTGATTTATGCGGCGTCCAGCATCGCGCTGGCTTGCCTGGAAACGCTGG
TCCACCTGGGTTCAGGCGGGCTGCCGCTGAACCGCTACCTGGTCCGGATCGACATCCCCGACGAGCTATGGGCGGCTGCG
CAGAAACTGAGCGTCGACACCGCCCCCGTAGGCTGGGATGCCATTCCCGCCGGAAAGACCAGCCTCGACACCGGCGAAGC
CTGGACCGCCGGGGGCACCAGCGCCTTGCTGCTGGTGCCTTCCATCGTCATCCCTGAAGAGCACAACGTGCTGGTCAACC
CGGCGCACCCCGACGCCGCGCGGCTGGCTTACGTCAAGGTCCGCCGCTGGCAGTACGACGCGCGCCTGGTCTGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14103.83 Da
• Isoelectric Point: 4.2376

>AT152170 WP_094976672.1 NZ_CP050066:c3237526-3237128 [Bradyrhizobium symbiodeficiens]
MRHYIGLIHKDADSDFGVSFPDLPGVVTAGSTLDEARDMAEEALAFHLEGLEEDGEAIPEPSSLEDIMSDPANRSGVAIL
VSVKDGQPKIVRVNVTLPGDVLEQIDKYAEAHGYTRSGLLAQAAKKLMTEAA

Nucleotide

• Length: 399 bp

>AT152170 NZ_CP066019:1345727-1346242 [Cupriavidus necator]
ATGCCGCTCATGCTCACTCCCAAAGGCCGCTATCCGCTGGCTCATGAACGCCCGGCTCCGCCCGAGCTGGGCGTCAACAA
CTACGTCGCCGTCTATGAGGCCAGCCTGTCGACGCAAGGCGCCATGTCGATCATCCGCGCGATTCGTGAAGGTGTGCCGG
CTTCAGACCTGAACCGCCTGGCCGAATCCATGGGCACCACCAAGGAGCAGCTGATCAAGACACTGGACTTGCCCCGCGCC
ACCGTGGACCGCAAGGCACGGGCGCACCAGAACCTGTCGAGCGAGCAGAGCGAGCGTGTGCTGGGCATGGCGCGGCTGGT
CGGGCAGGTCCAGGCGCTGGTGGAAAGCTCGGGCGATCCGCGCGGTTTCAGCGCGGCGCAGTGGGTGGCGCAGTGGCTGG
AGCAGCCTTCGCCGGCGCTGGGCGGGCGCCGCCCCGCTGAGCTGATGGATACGCTCGCCGGCCAGCGTATCGTTTCCGAC
CTGGTGGCCAGGATGCAGAGCGGGGCGTACGCGTGA