Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 8078349..8079879 Replicon chromosome
Accession NZ_CP050064
Organism Bradyrhizobium diazoefficiens strain 172S4

Toxin (Protein)


Gene name rlegT Uniprot ID A0A562QN92
Locus tag HAU57_RS37920 Protein ID WP_018647871.1
Coordinates 8078349..8079269 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A810CIT3
Locus tag HAU57_RS37925 Protein ID WP_026312796.1
Coordinates 8079259..8079879 (-) Length 207 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAU57_RS37905 8074324..8074842 - 519 Protein_7506 exonuclease subunit SbcD -
HAU57_RS37910 8074851..8076959 - 2109 WP_011084726.1 DUF87 domain-containing protein -
HAU57_RS37915 8076967..8078271 - 1305 WP_028176022.1 SIR2 family protein -
HAU57_RS37920 8078349..8079269 - 921 WP_018647871.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HAU57_RS37925 8079259..8079879 - 621 WP_026312796.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
HAU57_RS37930 8080093..8080839 - 747 WP_018647872.1 DCL family protein -
HAU57_RS37935 8080814..8083324 - 2511 WP_011084731.1 AAA family ATPase -
HAU57_RS37940 8083287..8083514 - 228 WP_131234255.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-264)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(12-56)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 34027.14 Da        Isoelectric Point: 5.2727

>T152168 WP_018647871.1 NZ_CP050064:c8079269-8078349 [Bradyrhizobium diazoefficiens]
MAREPRNIGASVRARLLDRARAERSDFQILLTRYALERLLYRLSASPHRDRFILKGAMLFVTWIADPFRPTRDLDLLGHG
DRDTEAIAETFRAICAQPVVDDGVTFDVAALMATPIREELEYGGVRVRTTATIAGARIPIQVDIGFGDAITPAAVEIDYP
TLLDAPTPHLRAYPVETVVAEKFAALVTLGVANSRLKDFYDLWVISRTFELRRAALAEAIQRTFERRGTVLPSVVPVGLT
DEFAETWAAQWRAFLERDRMAAAPDAFAVTVADLRLFLMPLVVGLKEERIWPPSGPWSPGAAIDEA

Download         Length: 921 bp

>T152168 NZ_CP066018:4003220-4003510 [Cupriavidus necator]
ATGAAGGAACCAACCCGCCCCTGGGACTCCGCCGAGCATCTGAGGAACGATCAGGAGATCGCCGCCTACCTGGATGCCTG
CCTGGCCGAGGCCGGCGACGACGATCGATTCATTGCCTACGCACTCGGGGTGGTGGCGCGTGCGCGCGGCATGACGCGAC
TGGCCCGCGAAACGGGCCTTTCGCGCGAAAGCCTCTACCGCTCGCTCTCAGGCGAAGGCAATCCGGAGTTCGGGACGATC
TGGAAGGTGATGCGGGCGCTGGGCATCCGCCTGCATGCGAGCGCTGGCTGA

Antitoxin


Download         Length: 207 a.a.        Molecular weight: 23385.28 Da        Isoelectric Point: 10.0691

>AT152168 WP_026312796.1 NZ_CP050064:c8079879-8079259 [Bradyrhizobium diazoefficiens]
MPSTSAQRLRALDLLKTRGMLRLKDFIAEGIGPETLARLVREEAVVRPARGLYQLPDAHLEAAHTLAEAAVLVPKGVVCL
TSALQYHELTLQMPSAVWMAIDRSAWRPKIDYPPIRFVRFTGSALTEGIERHRIENVDVPITDPARTIVDCFRYRTKIGL
DVAMEGLREGLRRRRCKPDQLWHYARKARVWSVMRPYVEAMVSDGA

Download         Length: 621 bp

>AT152168 NZ_CP066018:4002917-4003216 [Cupriavidus necator]
ATGCTCAGCATCCGGACAACCCAAATTTCCGACCGCTGGTATTCGGCCTTGCGCGACCACGTCGCCAGGATTCGCATCCA
GGTCCGCGTCGACCGCTTACTGAACGGGAATCCCGGCGACGCTAAAGCCCTTGGCGGTGGAGTCAGCGAAATGCGCGTGG
ACCACGGCCCGGGCTACCGCATCTACTTTCAGCAACGCGGCCAGGTAATTGTGATCCTGCTCTGCGGAGGCAACAAGTCG
ACCCAGCACGCTGATATCGAAAGAGCACGCAGTCTGGCGGCCAATCTTGATCTGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A562QN92

Antitoxin

Source ID Structure
AlphaFold DB A0A810CIT3

References