152161

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1283091..1283699 Replicon chromosome
Accession NZ_CP050053
Organism Pseudomonas aeruginosa strain LIUYANG-C

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag HAP36_RS05975 Protein ID WP_003114156.1
Coordinates 1283352..1283699 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HAP36_RS05970 Protein ID WP_003114155.1
Coordinates 1283091..1283342 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP36_RS05950 1278738..1279094 + 357 WP_003114150.1 DUF2523 domain-containing protein -
HAP36_RS05955 1279098..1280372 + 1275 WP_010895520.1 zonular occludens toxin family protein -
HAP36_RS05960 1280602..1281894 + 1293 WP_003115206.1 hypothetical protein -
HAP36_RS05965 1281894..1282877 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
HAP36_RS05970 1283091..1283342 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HAP36_RS05975 1283352..1283699 + 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAP36_RS05985 1284026..1284928 - 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
HAP36_RS05990 1285380..1286117 - 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
HAP36_RS05995 1286197..1287240 - 1044 WP_003098363.1 L,D-transpeptidase -
HAP36_RS06000 1287376..1288068 - 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
HAP36_RS06005 1288068..1288340 - 273 WP_010895521.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1275245..1286117 10872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T152161 WP_003114156.1 NZ_CP050053:1283352-1283699 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T152161 NZ_CP066015:c2492219-2491962 [Kytococcus sedentarius]
GTGAAGACGCTCAGCTACACCGAGTCACGCCGGCGATACGCCGAGGTGCTCGACCACGTGGTGGACGACCGCGAGGAGGT
CGTCATCACCCGCGCCGGGCACGAGCCCGTCGTCATCGTGTCCCTGGAGGAGTACGAGTCCCTCCGCGAGACCGCCTACC
TCATGCGGTCCCCGGCCAACGCCCGCCGCCTGCTCGACGCCATGGACCGCCTCGAGGCCGGCGGCGGCACCGAGCACGAG
CTGATCGAGACCGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT152161 WP_003114155.1 NZ_CP050053:1283091-1283342 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT152161 NZ_CP066015:c2491960-2491703 [Kytococcus sedentarius]
GTGCGCCTGGTCTGGGACGAGAACGCCTGGGAGGACTACCTCTGGTGGCAGGCCCAGGACCGCAAGGTGCTCAAGCGGAT
CAACACCCTGCTCAAGGACGTCGCCCGGAACGGCAACGAGGGCACCGGCAAGCCCGAGGCCCTGAAGCACAGCCTCGCCG
GGTACTGGTCCCGCCGCATCACCGACGAGCACCGCCTCGTCCACAAGGTCACCGAGGACGAGATCCGCATCGCAGCCTGC
CGGTACCACTACGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References