152157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4717413..4718021 Replicon chromosome
Accession NZ_CP050052
Organism Pseudomonas aeruginosa strain LIUYANG-E

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag HAP34_RS21805 Protein ID WP_003114156.1
Coordinates 4717413..4717760 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HAP34_RS21810 Protein ID WP_003114155.1
Coordinates 4717770..4718021 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP34_RS21775 4712772..4713044 + 273 WP_010895521.1 cysteine-rich CWC family protein -
HAP34_RS21780 4713044..4713736 + 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
HAP34_RS21785 4713872..4714915 + 1044 WP_003098363.1 L,D-transpeptidase -
HAP34_RS21790 4714995..4715732 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
HAP34_RS21795 4716184..4717086 + 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
HAP34_RS21805 4717413..4717760 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAP34_RS21810 4717770..4718021 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HAP34_RS21815 4718235..4719218 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
HAP34_RS21820 4719218..4720510 - 1293 WP_003115206.1 hypothetical protein -
HAP34_RS21825 4720740..4722014 - 1275 WP_010895520.1 zonular occludens toxin family protein -
HAP34_RS21830 4722018..4722374 - 357 WP_003114150.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4717413..4739611 22198


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T152157 WP_003114156.1 NZ_CP050052:c4717760-4717413 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T152157 NZ_CP066013:c1387874-1387653 [Staphylococcus equorum]
ATGGATGTAAAAGTAACAGTAATCGTAAGAGTATTAAGTTTAATTTTGGTGTTAGTGAACCAGTGGTTGTCAAATAAAGA
AGTGAGTCCTATTCCAGTGGATGAGTCAACACTAATGACTATCGCAGTCGCATTAATCACGATGTGGAAAGATAACCCAT
TTACAGATGCAGCTAAGGGTTCTTTTTTTAAATCTTATACTTATCAGCTTGAAATATTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT152157 WP_003114155.1 NZ_CP050052:c4718021-4717770 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT152157 NZ_CP066013:1387925-1388023 [Staphylococcus equorum]
ATTTGATAATATTTATATGTTGTGTTAATTTATATATAGAAAAAGGGCAACACACCATACGTGTATCGCCCCAATGAGCC
CGTTAAAAAGACGGTGGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References