Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3465214..3466435 Replicon chromosome
Accession NZ_CP050052
Organism Pseudomonas aeruginosa strain LIUYANG-E

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HAP34_RS15865 Protein ID WP_003114949.1
Coordinates 3465857..3466435 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HAP34_RS15860 Protein ID WP_003088112.1
Coordinates 3465214..3465768 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP34_RS15835 3460782..3461333 + 552 WP_003102727.1 XRE family transcriptional regulator -
HAP34_RS15840 3461330..3461728 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HAP34_RS15845 3461741..3462064 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HAP34_RS15850 3462395..3462856 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HAP34_RS15855 3462861..3465056 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HAP34_RS15860 3465214..3465768 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HAP34_RS15865 3465857..3466435 + 579 WP_003114949.1 HD domain-containing protein Toxin
HAP34_RS15870 3466543..3467730 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HAP34_RS15875 3467720..3469891 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
HAP34_RS15880 3469881..3471158 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T152155 WP_003114949.1 NZ_CP050052:3465857-3466435 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T152155 NZ_CP066013:554061-554423 [Staphylococcus equorum]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
TATCATACAGAATGATACTGGAAATAAATATAGTCCTACCGTAATTGTAGCTGCAATTACAGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAGCTTGATAAAGATTCTGTAATACTGCTTGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACATACCTTTCTGAAAGTAAAATGAAAGAAGTTAATGTTGCCATAGA
TATAAGCTTAGGATTACATAATGTTAGAAATAGTAAATCATGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152155 WP_003088112.1 NZ_CP050052:3465214-3465768 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152155 NZ_CP066013:553894-554064 [Staphylococcus equorum]
ATGGCAAGTTTTAATCAAAGCAGAAACCATAGTATTGAACAACTATTAAAAGAAGGCTATTCACAAATGGCCGATTTAAA
TCTCTCCCTTGCAGCAGAAGCATTTCCATTTGAATGTGAAGCTTGTGATTGCAATGAAGTTTACCTCAGCTCTAAGAATA
ACAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References