152151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 5733..6255 Replicon plasmid pCD90-1-2
Accession NZ_CP050049
Organism Escherichia coli strain 90-1

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag G9P52_RS23550 Protein ID WP_000220560.1
Coordinates 5733..6014 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag G9P52_RS23555 Protein ID WP_000121743.1
Coordinates 6004..6255 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P52_RS23525 782..1720 - 939 WP_077817178.1 IS5 family transposase -
G9P52_RS23530 2301..2687 + 387 WP_001039464.1 hypothetical protein -
G9P52_RS23535 2827..3795 - 969 WP_030005799.1 IS5 family transposase -
G9P52_RS23540 4643..4951 - 309 Protein_4 replication initiation protein -
G9P52_RS23545 4961..5658 - 698 Protein_5 IS1 family transposase -
G9P52_RS23550 5733..6014 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9P52_RS23555 6004..6255 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
G9P52_RS23560 7489..8325 + 837 WP_001050931.1 replication initiation protein -
G9P52_RS23565 8365..8811 + 447 Protein_9 hypothetical protein -
G9P52_RS23570 8879..9304 + 426 WP_000202942.1 hypothetical protein -
G9P52_RS23575 9301..10278 - 978 WP_024245156.1 hypothetical protein -
G9P52_RS23580 10303..10584 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(6)-Id / sul3 / blaTEM-1B / qnrS1 - 1..27018 27018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T152151 WP_000220560.1 NZ_CP050049:c6014-5733 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T152151 NZ_CP066010:340-621 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT152151 WP_000121743.1 NZ_CP050049:c6255-6004 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT152151 NZ_CP066010:74-343 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References