Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3334348..3334979 Replicon chromosome
Accession NZ_CP050047
Organism Escherichia coli strain 90-1

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag G9P52_RS15895 Protein ID WP_001259385.1
Coordinates 3334348..3334623 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag G9P52_RS15900 Protein ID WP_000593554.1
Coordinates 3334620..3334979 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P52_RS15880 3329352..3330419 + 1068 WP_000361470.1 HlyD family secretion protein -
G9P52_RS15885 3330416..3333151 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
G9P52_RS15890 3333151..3334275 + 1125 WP_001314210.1 ABC transporter permease -
G9P52_RS15895 3334348..3334623 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
G9P52_RS15900 3334620..3334979 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G9P52_RS15905 3335029..3335889 - 861 WP_001131783.1 class II aldolase -
G9P52_RS15910 3335921..3336190 - 270 WP_000933060.1 HPr family phosphocarrier protein -
G9P52_RS15915 3336180..3337688 - 1509 WP_001298718.1 carbohydrate kinase -
G9P52_RS15920 3337681..3339039 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
G9P52_RS15925 3339116..3339397 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
G9P52_RS15930 3339394..3339867 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3326019..3340638 14619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T152140 WP_001259385.1 NZ_CP050047:3334348-3334623 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T152140 NZ_CP065997:c4056070-4055768 [Achromobacter deleyi]
GTGAGGGCATTGCGCTGGACGCCCGAAGCGATCCAGGACCGGGAAGCGATCTACGATTTCATCGAGGCCGACAACCCCAT
TGCGGCGCTGACGCTTGATGAACTTCTTGAAGAGAAGGCGGGACGCCTGATCGATCATCCCGGCCTGGGTCGTCCCGGCC
GTGTCGCGGGCACCCGGGAGCTGGTGGCGCACCCGAACTATCTATTGATCTACGACGTGACGAACGATCTCGTGCGCATG
CTGCGTGTGCTGCATGCGGCCCGGCAGTGGCCAACGCCGGATCCATCATCTGAGAGTCGCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT152140 WP_000593554.1 NZ_CP050047:3334620-3334979 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT152140 NZ_CP065997:c4056354-4056067 [Achromobacter deleyi]
ATGAGCGACGCTACCTTTACCTTTCGGGTGGATGAAGCCTTGAAAAACGAGTTCGCCATGGCCGCCAAGGCCCGAGACCG
CACCGGCGCGCAGCTTCTGCGCGACTTCATGCGGGAGTACGTCCAGCAACAACAGGAAGCGGCCCAGCATGACGCCTGGT
TCCGCCGCCAGGTGCAAGCGGGCCTGGATTCCGCCAACGCCGGCCGCCTGGTGCCGGCCGCCGAGGTCGAAACCAAATTC
GCAGCCCGTCGCGCCGCGACCCGTCGCCGGCTTGAAACACCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References