Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2447064..2447659 Replicon chromosome
Accession NZ_CP050047
Organism Escherichia coli strain 90-1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag G9P52_RS11850 Protein ID WP_000239579.1
Coordinates 2447064..2447414 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag G9P52_RS11855 Protein ID WP_001223208.1
Coordinates 2447408..2447659 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P52_RS11830 2442340..2443362 - 1023 WP_001296689.1 ABC transporter permease -
G9P52_RS11835 2443376..2444878 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
G9P52_RS11840 2445188..2446144 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
G9P52_RS11845 2446454..2446984 + 531 WP_000055072.1 inorganic diphosphatase -
G9P52_RS11850 2447064..2447414 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
G9P52_RS11855 2447408..2447659 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
G9P52_RS11860 2447872..2448213 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
G9P52_RS11865 2448216..2451995 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T152136 WP_000239579.1 NZ_CP050047:c2447414-2447064 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T152136 NZ_CP065989:2339617-2339898 [Brevibacterium casei]
GTGATCAGACCGTTCGGCGACAAGGAGACCGAGCGGCTGTGGCACCGTGAACGCGTGCGCTCGATCGATCCGCGGATCCT
CCGAGTCGCGTTGCGCAAGCTGCGTCAGCTGGGTTCTGCGGAGGCTCTCGAAGATCTCCGTGTCCCGCCCGGCAATCGGC
TCGAGGCACTCAAGGGTGATCGGGCCGGTCAGCACAGCATCAGGATCAACGACCAGTGGCGGATCTGTTTCGTGTGGACC
GACGCCGGACCAGAGGAGGTGGAGATTGTTGACTACCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT152136 WP_001223208.1 NZ_CP050047:c2447659-2447408 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT152136 NZ_CP065989:2339885-2340187 [Brevibacterium casei]
TTGACTACCACTGACAAGATCGAGCCGATCCACCCAGGGGAGGTCCTCATGGAGGACTTCATCGAGGGATTCGGTATCAC
CCAGAACAAACTCGCCGTGTCGATCGGCGTCCCTCCCAGGCGGATCAATGAGATCGTGCACGGCAAGCGCGGGATCACCG
CAGACACAGCACTGCGTCTCGCGAGGTACTTCGGCACGTCTGCGGAGTTCTGGATCAACCTGCAGAGTCACTACGAGCTC
GACCGTGCGGAAGAACTCGCGGGGGAGCAGATCGCTTCGATCACTCCATTGAGCGTCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References