Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1762691..1763309 Replicon chromosome
Accession NZ_CP050047
Organism Escherichia coli strain 90-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G9P52_RS08590 Protein ID WP_001291435.1
Coordinates 1763091..1763309 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G9P52_RS08585 Protein ID WP_000344800.1
Coordinates 1762691..1763065 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P52_RS08575 1757780..1758973 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G9P52_RS08580 1758996..1762145 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
G9P52_RS08585 1762691..1763065 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G9P52_RS08590 1763091..1763309 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
G9P52_RS08595 1763481..1764032 + 552 WP_000102564.1 maltose O-acetyltransferase -
G9P52_RS08600 1764148..1764618 + 471 WP_000136192.1 YlaC family protein -
G9P52_RS08605 1764782..1766332 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G9P52_RS08610 1766374..1766727 - 354 WP_000878141.1 DUF1428 family protein -
G9P52_RS08620 1767106..1767417 + 312 WP_000409911.1 MGMT family protein -
G9P52_RS08625 1767448..1768020 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T152132 WP_001291435.1 NZ_CP050047:1763091-1763309 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T152132 NZ_CP065980:1622789-1622941 [Staphylococcus felis]
ATGTATCAAGACAAAAAAGATTATGATAATGAAATGGTCGATGGTTTTGACGATATGGTAGAACTTGGTAAGGAGATGGA
ACAAATTTCTGAAGAAAATGACCAAGAAAAGCTCAATCAAGACCATAATCAAGCAGTGCGTTCTGATAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT152132 WP_000344800.1 NZ_CP050047:1762691-1763065 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT152132 NZ_CP065980:1622172-1622771 [Staphylococcus felis]
ATGGCAATGAATTTTAAAATTTTTAAAGATGCAGATACAGCAGCGCTTTATACAGCTGATATTATTAGAAAACAATTTAA
TAATAATCCGACTACAATCGCAGGTATTCACTTAAATAATGAAGATGCGCCAGTACTAGAAGCGTTGAAAAAAAGCGTTG
ATGATCATGCGGTAGATTTTAGCCAAATTCATATTTTAGATTACGATAAAAAAACATCTTACTATAAAGCTTTAGGTGTG
CCAGAAAAACAAGTGCATGAAATTGCAGAAGAAGAGCAAGTGGAGAGTTTTATCGAGCACCATGCTAAAACAAAAAATAA
TAAAGGTAAATTAACGCTTCAAGTTGTGACAATAGATCAAAAAGGTTATCTTGGTGTAGGGATGAAAGAAGGTATACTCC
CTGCTCGTGAAATTATTTTAGTTATCACTGGTGACTACAAAGCAGATTTAGTAAAAAAACTATATGAAGAAAATGGGAAT
ACAAGTTTTATCCCATCGACACTTAAACAGCATAGAATGGTCAATGTGGTTTTAGATGAAGCTGCTGCACAAGGGCTACC
TGAAGATGTCCGTTCGTATTTCACTTCATTATATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References