Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 694322..694960 Replicon chromosome
Accession NZ_CP050047
Organism Escherichia coli strain 90-1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag G9P52_RS03395 Protein ID WP_000813794.1
Coordinates 694784..694960 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G9P52_RS03390 Protein ID WP_001270286.1
Coordinates 694322..694738 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P52_RS03370 689474..690415 - 942 WP_001251315.1 ABC transporter permease -
G9P52_RS03375 690416..691429 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
G9P52_RS03380 691447..692592 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
G9P52_RS03385 692837..694243 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
G9P52_RS03390 694322..694738 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
G9P52_RS03395 694784..694960 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
G9P52_RS03400 695182..695412 + 231 WP_000494244.1 YncJ family protein -
G9P52_RS03405 695504..697465 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
G9P52_RS03410 697538..698074 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
G9P52_RS03415 698127..699341 + 1215 WP_001307190.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T152131 WP_000813794.1 NZ_CP050047:c694960-694784 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T152131 NZ_CP065980:1414617-1414976 [Staphylococcus felis]
ATGAAGCGAGGAGACGTTTATTTAGCAGATCTCTCTCCAGTACAAGGGTCCGAACAAGGGGGAGTAAGACCCGTCGTTAT
TATTCAAAATGATACTGGAAACAAATACAGTCCAACAGTTATAGTTGCTGCTATAACAGGTAGGATTAATAAAGCTAAAA
TACCCACTCATGTTGAAATTGAAAAACAGAAATATAAGTTAGACAAAGATTCTGTTATCCTGTTAGAACAAATTAGAACA
GTAGATAAAAAGAGGCTGAAGGAGAAATTGACATATTTATCAGATGAGAAGATGAAGGAAGTCAATAATGCTCTTGGTAT
CAGCTTAGGATTGCATATGAATCAGTCTAAAAAAGACTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT152131 WP_001270286.1 NZ_CP050047:c694738-694322 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT152131 NZ_CP065980:1414446-1414616 [Staphylococcus felis]
ATGTCAACATTCAATCAAACAAGATTTAAAAATAATCTAGAACAGTCTTTAAAAGAAGGTTACGTACAAATGGCTGACCT
AAATCTCTCCCTAGCAACCGAAGCCTACTCAGTAGAATGTGAAGCTTGTGACTGTAACGAATCTCACTTAACGAATAGCA
AGGATGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References