Detailed information of TA system TA152130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 595427..597015
• Replicon: chromosome
• Accession: NZ_CP050047
• Organism: Escherichia coli strain 90-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: G9P52_RS02980
• Protein ID: WP_001125463.1
• Coordinates: 595693..597015 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: G9P52_RS02975
• Protein ID: WP_001296726.1
• Coordinates: 595427..595693 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9P52_RS02975	595427..595693	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
G9P52_RS02980	595693..597015	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
G9P52_RS02985	597301..598248	-	948	WP_089634762.1	hypothetical protein	-
G9P52_RS02990	599061..600152	-	1092	WP_188027935.1	hypothetical protein	-
G9P52_RS02995	600547..600755	+	209	Protein_587	helix-turn-helix transcriptional regulator	-
G9P52_RS03000	601187..601750	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T152130 WP_001125463.1 NZ_CP050047:595693-597015 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T152130 NZ_CP065980:1401272-1401496 [Staphylococcus felis]
ATGTATCAAAGTTATGTGCAAGTCTCGAACATTCATACAGAAAATGATAAAGAAGCTTTAGAAAAACGTTTATCTTCTAT
GATTGGGGTATTGGATGTTCAAATTGATATCAATCAGCAATGTGTCAACCTAGAATATGAAACACCAGCAAATCTTAACA
CGTTAGAAAAAGAAATCTATGATGCAGGTTTTCCTGTTATCAATTCATTCAAAGGAGGATATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT152130 WP_001296726.1 NZ_CP050047:595427-595693 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT152130 NZ_CP065980:1400972-1401259 [Staphylococcus felis]
ATGACTGAACAAGCACATCATTCTGATTCGATAAAGCGTAATTTAAAGTCGCGTTTGAATCGCATTGAAGGACAAGTACG
TGCCATCAATCGTATGATAGATGAAGATGTCTATTGTGATGATGTTTTAACGCAAATTAGAGCAACACGATCTGCTTTAA
ATAGCGTAGCGACAAAATTATTAGATTATCACATGAAAGGTTGTATTATGCATAAAATTGAAAATGGTTCTGAACAAGAA
GCTATGGAAGAATTACTTGTGACGTTCCAGAAATTAATGAAAGACTAA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0