152094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3880528..3881342 Replicon chromosome
Accession NZ_CP050040
Organism Escherichia coli strain 63-2

Toxin (Protein)


Gene name yjhX Uniprot ID A0A6C9SL90
Locus tag G9P50_RS18505 Protein ID WP_001054375.1
Coordinates 3880528..3880785 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag G9P50_RS18510 Protein ID WP_001309181.1
Coordinates 3880797..3881342 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P50_RS18485 3875816..3876922 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
G9P50_RS18490 3876987..3877967 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
G9P50_RS18495 3878550..3879536 - 987 WP_182143943.1 hypothetical protein -
G9P50_RS18500 3879906..3880151 + 246 Protein_3612 GNAT family N-acetyltransferase -
G9P50_RS18505 3880528..3880785 + 258 WP_001054375.1 hypothetical protein Toxin
G9P50_RS18510 3880797..3881342 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
G9P50_RS18515 3881398..3882144 + 747 WP_000354252.1 class I SAM-dependent methyltransferase -
G9P50_RS18520 3882313..3882531 + 219 Protein_3616 hypothetical protein -
G9P50_RS18525 3882930..3884051 + 1122 WP_000010831.1 M42 family metallopeptidase -
G9P50_RS18530 3884048..3884326 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
G9P50_RS18535 3884338..3885651 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9768.31 Da        Isoelectric Point: 11.0090

>T152094 WP_001054375.1 NZ_CP050040:3880528-3880785 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR

Download         Length: 258 bp

>T152094 NZ_CP065965:7852-8157 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19938.86 Da        Isoelectric Point: 6.3277

>AT152094 WP_001309181.1 NZ_CP050040:3880797-3881342 [Escherichia coli]
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT152094 NZ_CP065965:8198-8500 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9SL90

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References