152091

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3333498..3334116 Replicon chromosome
Accession NZ_CP050040
Organism Escherichia coli strain 63-2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G9P50_RS15900 Protein ID WP_001291435.1
Coordinates 3333898..3334116 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G9P50_RS15895 Protein ID WP_000344800.1
Coordinates 3333498..3333872 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P50_RS15885 3328587..3329780 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G9P50_RS15890 3329803..3332952 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
G9P50_RS15895 3333498..3333872 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G9P50_RS15900 3333898..3334116 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
G9P50_RS15905 3334288..3334839 + 552 WP_000102564.1 maltose O-acetyltransferase -
G9P50_RS15910 3334955..3335425 + 471 WP_000136192.1 YlaC family protein -
G9P50_RS15915 3335589..3337139 + 1551 WP_165899047.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G9P50_RS15920 3337181..3337534 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G9P50_RS15930 3337913..3338224 + 312 WP_000409911.1 MGMT family protein -
G9P50_RS15935 3338255..3338827 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T152091 WP_001291435.1 NZ_CP050040:3333898-3334116 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T152091 NZ_CP065960:163541-163912 [Mammaliicoccus sciuri]
ATGAGAAGAGGAGATGTATATCTCGCAGATCTTTCACCAGTTACAGGTTCTGAACAAGGGGGAACAAGACCAGTCGTTAT
TATCCAGAATGATACAGGTAATCGATACAGCCCGACTGTGATTGTTGCAGCAATTACTGGTAAGATAAATAAAGCCAAAA
TTCCCACTCATGTAGAAATTGAGGCAGCGAAATATAAATTAGACAGAGATTCCGTAATTTTGCTTGAACAAATCAGAACT
ATTGATAAAAAACGCTTAAAAGAAAAATTAACATATTTATCTGATGCAAAGATGAAAGAGGTTGATACTGCTATTGCAAT
CAGCCTCAATCTAACTTTGCAACAAAAATTTGATACATTAGGTAATACATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT152091 WP_000344800.1 NZ_CP050040:3333498-3333872 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT152091 NZ_CP065960:163373-163540 [Mammaliicoccus sciuri]
ATGACATCTTTAACGCAAAATCGTACACAAAGTTTAGAACAAACACTGAAAGAAGGCTATCGTTCAATGGCCGATTTAAA
TCTCTCCCTTGCATCTGAAGCATACTATTGTGAATGTGAAGCTTGTGATTCAAATGAATCGCATATAGCCTCTCAGCAAG
GTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References