Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 18654..19176 Replicon plasmid pCD58-3-1
Accession NZ_CP050037
Organism Escherichia coli strain 58-3

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag G9P49_RS22585 Protein ID WP_000220560.1
Coordinates 18654..18935 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag G9P49_RS22590 Protein ID WP_000121743.1
Coordinates 18925..19176 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P49_RS22560 13703..14641 - 939 WP_077817178.1 IS5 family transposase -
G9P49_RS22565 15222..15608 + 387 WP_001039464.1 hypothetical protein -
G9P49_RS22570 15748..16716 - 969 WP_030005799.1 IS5 family transposase -
G9P49_RS22575 17564..17872 - 309 Protein_16 replication initiation protein -
G9P49_RS22580 17882..18579 - 698 Protein_17 IS1-like element IS1A family transposase -
G9P49_RS22585 18654..18935 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9P49_RS22590 18925..19176 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
G9P49_RS22595 20410..21246 + 837 WP_001050931.1 replication initiation protein -
G9P49_RS22600 21286..21732 + 447 Protein_21 hypothetical protein -
G9P49_RS22605 21800..22225 + 426 WP_000202942.1 hypothetical protein -
G9P49_RS22610 22222..23199 - 978 WP_024245156.1 hypothetical protein -
G9P49_RS22615 23224..23505 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sul3 / blaTEM-1B / qnrS1 / aph(6)-Id / dfrA14 / tet(X4) / floR / tet(A) - 1..44691 44691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T152073 WP_000220560.1 NZ_CP050037:c18935-18654 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T152073 NZ_CP065948:c4291987-4291709 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT152073 WP_000121743.1 NZ_CP050037:c19176-18925 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT152073 NZ_CP065948:c4291697-4291392 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCCGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References