152051

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 22898..23420 Replicon plasmid pCD33-6-1
Accession NZ_CP050032
Organism Escherichia coli strain 33-6

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag G9P48_RS22660 Protein ID WP_000220560.1
Coordinates 23139..23420 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag G9P48_RS22655 Protein ID WP_000121743.1
Coordinates 22898..23149 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P48_RS22630 18569..18850 + 282 WP_001185482.1 hypothetical protein -
G9P48_RS22635 18875..19852 + 978 WP_024245156.1 hypothetical protein -
G9P48_RS22640 19849..20274 - 426 WP_000202942.1 hypothetical protein -
G9P48_RS22645 20342..20788 - 447 Protein_21 hypothetical protein -
G9P48_RS22650 20828..21664 - 837 WP_001050931.1 replication initiation protein -
G9P48_RS22655 22898..23149 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
G9P48_RS22660 23139..23420 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9P48_RS22665 23495..24188 + 694 Protein_25 IS1 family transposase -
G9P48_RS22670 24198..24506 + 309 Protein_26 replication initiation protein -
G9P48_RS22675 26093..27061 + 969 WP_030005799.1 IS5 family transposase -
G9P48_RS22680 27201..27587 - 387 WP_001039464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS1 / blaTEM-1B / sul3 / dfrA14 / aph(6)-Id - 1..30707 30707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T152051 WP_000220560.1 NZ_CP050032:23139-23420 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T152051 NZ_CP065939:c3946731-3946321 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTACACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT152051 WP_000121743.1 NZ_CP050032:22898-23149 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT152051 NZ_CP065939:c3946978-3946712 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References