152049

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4046546..4047249 Replicon chromosome
Accession NZ_CP050031
Organism Escherichia coli strain 33-6

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8T6BCS1
Locus tag G9P48_RS19510 Protein ID WP_001616568.1
Coordinates 4046546..4046887 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A377WBK0
Locus tag G9P48_RS19515 Protein ID WP_053274373.1
Coordinates 4046908..4047249 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P48_RS19500 4041761..4044877 + 3117 WP_182116786.1 HsdR family type I site-specific deoxyribonuclease -
G9P48_RS19505 4045284..4046291 - 1008 WP_049017154.1 restriction endonuclease -
G9P48_RS19510 4046546..4046887 - 342 WP_001616568.1 TA system toxin CbtA family protein Toxin
G9P48_RS19515 4046908..4047249 - 342 WP_053274373.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G9P48_RS19520 4047260..4047802 - 543 WP_062896416.1 DNA repair protein RadC -
G9P48_RS19525 4047815..4048255 - 441 WP_053274374.1 antirestriction protein -
G9P48_RS19530 4048286..4049107 - 822 WP_115720769.1 DUF945 domain-containing protein -
G9P48_RS19535 4049205..4049435 - 231 WP_139914620.1 DUF905 domain-containing protein -
G9P48_RS19540 4049507..4049956 - 450 WP_115720771.1 hypothetical protein -
G9P48_RS19545 4049953..4050408 - 456 WP_053274378.1 hypothetical protein -
G9P48_RS19550 4050447..4051082 - 636 WP_053274379.1 hypothetical protein -
G9P48_RS19555 4051079..4051792 - 714 WP_053274380.1 sporulation transcriptional regulator SpoIIID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12746.75 Da        Isoelectric Point: 9.6548

>T152049 WP_001616568.1 NZ_CP050031:c4046887-4046546 [Escherichia coli]
MKTLPATTPQAAKLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T152049 NZ_CP065939:c2935835-2935732 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12773.41 Da        Isoelectric Point: 6.6253

>AT152049 WP_053274373.1 NZ_CP050031:c4047249-4046908 [Escherichia coli]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT152049 NZ_CP065939:2935725-2935928 [Enterobacter hormaechei]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTG
GTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A377WBK0

References