Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4204806..4205475 Replicon chromosome
Accession NZ_CP050013
Organism Serratia marcescens strain BP2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HAP49_RS20020 Protein ID WP_004931681.1
Coordinates 4204806..4205228 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag HAP49_RS20025 Protein ID WP_004931679.1
Coordinates 4205209..4205475 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP49_RS20000 4200733..4202466 - 1734 WP_015378966.1 single-stranded-DNA-specific exonuclease RecJ -
HAP49_RS20005 4202473..4203189 - 717 WP_004931688.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HAP49_RS20010 4203216..4204115 - 900 WP_004931685.1 site-specific tyrosine recombinase XerD -
HAP49_RS20015 4204222..4204740 + 519 WP_004931683.1 flavodoxin FldB -
HAP49_RS20020 4204806..4205228 - 423 WP_004931681.1 protein YgfX Toxin
HAP49_RS20025 4205209..4205475 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
HAP49_RS20030 4205796..4206788 + 993 WP_015378968.1 tRNA-modifying protein YgfZ -
HAP49_RS20035 4206827..4207324 - 498 WP_044030541.1 DUF2165 domain-containing protein -
HAP49_RS20040 4207475..4208149 - 675 WP_021505704.1 hemolysin III family protein -
HAP49_RS20045 4208333..4208941 + 609 WP_004931670.1 HD domain-containing protein -
HAP49_RS20050 4208982..4209908 - 927 WP_021505706.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16487.59 Da        Isoelectric Point: 11.0198

>T152025 WP_004931681.1 NZ_CP050013:c4205228-4204806 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQG

Download         Length: 423 bp

>T152025 NZ_CP065925:742873-743094 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT152025 WP_004931679.1 NZ_CP050013:c4205475-4205209 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT152025 NZ_CP065925:742573-742860 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References