Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3852667..3853323 Replicon chromosome
Accession NZ_CP050013
Organism Serratia marcescens strain BP2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HAP49_RS18360 Protein ID WP_021504433.1
Coordinates 3852667..3853056 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag HAP49_RS18365 Protein ID WP_004941563.1
Coordinates 3853060..3853323 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP49_RS18345 3849134..3850564 + 1431 WP_166445311.1 multidrug transporter subunit MdtD -
HAP49_RS18350 3850561..3851943 + 1383 WP_004941570.1 two-component system sensor histidine kinase BaeS -
HAP49_RS18355 3851943..3852659 + 717 WP_015378739.1 two-component system response regulator BaeR -
HAP49_RS18360 3852667..3853056 - 390 WP_021504433.1 type II toxin-antitoxin system VapC family toxin Toxin
HAP49_RS18365 3853060..3853323 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HAP49_RS18370 3853661..3853999 + 339 WP_004941561.1 YegP family protein -
HAP49_RS18375 3854178..3855530 + 1353 WP_004941558.1 tRNA 5-hydroxyuridine modification protein YegQ -
HAP49_RS18380 3855997..3856902 + 906 WP_166445312.1 lipid kinase YegS -
HAP49_RS18385 3857071..3858285 + 1215 WP_166445313.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14398.63 Da        Isoelectric Point: 8.4983

>T152023 WP_021504433.1 NZ_CP050013:c3853056-3852667 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T152023 NZ_CP065924:864040-864393 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT152023 WP_004941563.1 NZ_CP050013:c3853323-3853060 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT152023 NZ_CP065924:863869-864039 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References