Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3765942..3766504 Replicon chromosome
Accession NZ_CP050013
Organism Serratia marcescens strain BP2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HAP49_RS17950 Protein ID WP_021505635.1
Coordinates 3765942..3766298 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag HAP49_RS17955 Protein ID WP_004936539.1
Coordinates 3766295..3766504 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP49_RS17930 3761678..3762475 - 798 WP_166445301.1 TonB family protein -
HAP49_RS17935 3762578..3763417 - 840 WP_166445537.1 ChaN family lipoprotein -
HAP49_RS17940 3763595..3765004 + 1410 WP_015378686.1 S-methylmethionine permease -
HAP49_RS17945 3764994..3765932 + 939 WP_099982391.1 homocysteine S-methyltransferase -
HAP49_RS17950 3765942..3766298 - 357 WP_021505635.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HAP49_RS17955 3766295..3766504 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HAP49_RS17960 3766614..3768893 - 2280 WP_004936542.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
HAP49_RS17965 3769108..3769281 - 174 WP_165385135.1 hypothetical protein -
HAP49_RS17970 3769262..3769642 - 381 WP_044030723.1 DUF2570 family protein -
HAP49_RS17975 3769639..3770040 - 402 WP_033643981.1 M15 family metallopeptidase -
HAP49_RS17980 3770030..3770356 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13169.89 Da        Isoelectric Point: 4.7274

>T152022 WP_021505635.1 NZ_CP050013:c3766298-3765942 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEQQRRLTE

Download         Length: 357 bp

>T152022 NZ_CP065924:847920-848141 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT152022 WP_004936539.1 NZ_CP050013:c3766504-3766295 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT152022 NZ_CP065924:847620-847907 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References