Detailed information of TA system TA152020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3055045..3055673
• Replicon: chromosome
• Accession: NZ_CP050013
• Organism: Serratia marcescens strain BP2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HAP49_RS14560
• Protein ID: WP_166445200.1
• Coordinates: 3055045..3055248 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A086GDG8
• Locus tag: HAP49_RS14565
• Protein ID: WP_015378231.1
• Coordinates: 3055260..3055673 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP49_RS14555	3050910..3054881	+	3972	WP_033632771.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
HAP49_RS14560	3055045..3055248	+	204	WP_166445200.1	type II toxin-antitoxin system HicA family toxin	Toxin
HAP49_RS14565	3055260..3055673	+	414	WP_015378231.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HAP49_RS14570	3055703..3056455	-	753	WP_033632770.1	L-cystine ABC transporter ATP-binding protein YecC	-
HAP49_RS14575	3056459..3057121	-	663	WP_015378233.1	cystine ABC transporter permease	-
HAP49_RS14580	3057121..3057921	-	801	WP_015378234.1	cystine ABC transporter substrate-binding protein	-
HAP49_RS14585	3058037..3059029	-	993	WP_099981717.1	D-cysteine desulfhydrase	-
HAP49_RS14590	3059154..3059663	-	510	WP_004934751.1	flagella biosynthesis regulatory protein FliZ	-
HAP49_RS14595	3059718..3060440	-	723	WP_004934752.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliZ / fliA / fliS	3048855..3066733	17878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7549.98 Da
• Isoelectric Point: 11.1475

>T152020 WP_166445200.1 NZ_CP050013:3055045-3055248 [Serratia marcescens]
VKSLELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPKKDLKLGTLRQILKDAGLSALHIATR

Nucleotide

• Length: 204 bp

>T152020 NZ_CP065921:824048-824401 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14888.63 Da
• Isoelectric Point: 5.4867

>AT152020 WP_015378231.1 NZ_CP050013:3055260-3055673 [Serratia marcescens]
MFYPAYIHTESNGSASGFFPDVPGCYFAGTSLDDAFADAQSALDAHFELLSEDNQPLPRPHAVAAHLAKDAGSFEGGQWL
LVAINMDKFDGRAERINITLPHRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKAE

Nucleotide

• Length: 414 bp

>AT152020 NZ_CP065921:823877-824047 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A086GDG8