Detailed information of TA system TA152011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1788759..1789284
• Replicon: chromosome
• Accession: NZ_CP050013
• Organism: Serratia marcescens strain BP2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HAP49_RS08520
• Protein ID: WP_015377296.1
• Coordinates: 1788759..1789043 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: HAP49_RS08525
• Protein ID: WP_004928423.1
• Coordinates: 1789033..1789284 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP49_RS08495	1784019..1785152	+	1134	WP_004938650.1	putrescine ABC transporter ATP-binding subunit PotG	-
HAP49_RS08500	1785177..1786139	+	963	WP_021504359.1	putrescine ABC transporter permease PotH	-
HAP49_RS08505	1786136..1786981	+	846	WP_004938644.1	putrescine ABC transporter permease PotI	-
HAP49_RS08510	1787086..1787565	+	480	WP_015377294.1	YbjO family protein	-
HAP49_RS08515	1787635..1788762	+	1128	WP_015377295.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
HAP49_RS08520	1788759..1789043	-	285	WP_015377296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HAP49_RS08525	1789033..1789284	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
HAP49_RS08530	1789386..1790120	-	735	WP_015377297.1	arginine ABC transporter substrate-binding protein	-
HAP49_RS08535	1790319..1790987	-	669	WP_015377298.1	arginine ABC transporter permease ArtM	-
HAP49_RS08540	1790987..1791703	-	717	WP_004928413.1	arginine ABC transporter permease ArtQ	-
HAP49_RS08545	1791713..1792444	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
HAP49_RS08550	1792477..1793205	-	729	WP_004928406.1	arginine ABC transporter ATP-binding protein ArtP	-
HAP49_RS08555	1793468..1794010	-	543	WP_015377301.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10803.94 Da
• Isoelectric Point: 10.6941

>T152011 WP_015377296.1 NZ_CP050013:c1789043-1788759 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHIPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T152011 NZ_CP065918:3552335-3552631 [Yersinia pestis EV NIIEG]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT152011 WP_004928423.1 NZ_CP050013:c1789284-1789033 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT152011 NZ_CP065918:3552631-3553029 [Yersinia pestis EV NIIEG]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1