Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1659334..1659887 Replicon chromosome
Accession NZ_CP050013
Organism Serratia marcescens strain BP2

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1Q5WDY9
Locus tag HAP49_RS07945 Protein ID WP_015377213.1
Coordinates 1659573..1659887 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1Q5WDV0
Locus tag HAP49_RS07940 Protein ID WP_015377212.1
Coordinates 1659334..1659570 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP49_RS07925 1655800..1657335 + 1536 WP_004938996.1 glutathione ABC transporter substrate-binding protein GsiB -
HAP49_RS07930 1657388..1658308 + 921 WP_004938995.1 glutathione ABC transporter permease GsiC -
HAP49_RS07935 1658318..1659226 + 909 WP_176326010.1 glutathione ABC transporter permease GsiD -
HAP49_RS07940 1659334..1659570 + 237 WP_015377212.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HAP49_RS07945 1659573..1659887 + 315 WP_015377213.1 CcdB family protein Toxin
HAP49_RS07950 1659924..1660766 - 843 WP_015377214.1 S-formylglutathione hydrolase -
HAP49_RS07955 1660781..1661905 - 1125 WP_076740425.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
HAP49_RS07960 1661935..1662855 - 921 WP_004938975.1 LysR family transcriptional regulator -
HAP49_RS07965 1662961..1664118 + 1158 WP_099981700.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11662.55 Da        Isoelectric Point: 4.7085

>T152010 WP_015377213.1 NZ_CP050013:1659573-1659887 [Serratia marcescens]
MQFTVYANSGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRSRIKAAIDFLLDGI

Download         Length: 315 bp

>T152010 NZ_CP065918:3537926-3538351 [Yersinia pestis EV NIIEG]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9125.16 Da        Isoelectric Point: 6.4641

>AT152010 WP_015377212.1 NZ_CP050013:1659334-1659570 [Serratia marcescens]
MPVKQRTTQSVTMTLERSLLSRAREAGINLSATLTAALDAELRQHERRKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp

>AT152010 NZ_CP065918:3537679-3537945 [Yersinia pestis EV NIIEG]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q5WDY9

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q5WDV0

References