Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 41473..42116 Replicon plasmid unnamed2
Accession NZ_CP050011
Organism Citrobacter sp. Y3

Toxin (Protein)


Gene name vagD Uniprot ID A0A330DBA3
Locus tag HAP28_RS25840 Protein ID WP_024553480.1
Coordinates 41700..42116 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A330D345
Locus tag HAP28_RS25835 Protein ID WP_024553479.1
Coordinates 41473..41703 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP28_RS25805 37162..38037 + 876 WP_061549451.1 hypothetical protein -
HAP28_RS25810 38101..38286 - 186 WP_061549450.1 hypothetical protein -
HAP28_RS25815 38441..38839 + 399 WP_061549449.1 hypothetical protein -
HAP28_RS25820 39807..40037 + 231 WP_061549448.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HAP28_RS25825 40034..40450 + 417 WP_061549447.1 type II toxin-antitoxin system VapC family toxin -
HAP28_RS25830 40640..40966 + 327 WP_071789783.1 four-helix bundle copper-binding protein -
HAP28_RS25835 41473..41703 + 231 WP_024553479.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HAP28_RS25840 41700..42116 + 417 WP_024553480.1 type II toxin-antitoxin system VapC family toxin Toxin
HAP28_RS25850 43522..45486 + 1965 WP_166444370.1 NERD domain-containing protein -
HAP28_RS25855 45852..46082 + 231 WP_166444357.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HAP28_RS25860 46079..46495 + 417 WP_166444358.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89705 89705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15063.53 Da        Isoelectric Point: 7.7814

>T152007 WP_024553480.1 NZ_CP050011:41700-42116 [Citrobacter sp. Y3]
VNKIYMLDTCICSFIMREQPEAVLKRLEQAVLRNHRIVVSAITYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFARVPGLILEDWVN

Download         Length: 417 bp

>T152007 NZ_CP065918:1873771-1873864 [Yersinia pestis EV NIIEG]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8663.74 Da        Isoelectric Point: 4.3654

>AT152007 WP_024553479.1 NZ_CP050011:41473-41703 [Citrobacter sp. Y3]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFMAEREDVVTDEGRVDL

Download         Length: 231 bp

>AT152007 NZ_CP065918:c1873865-1873771 [Yersinia pestis EV NIIEG]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330DBA3

Antitoxin

Source ID Structure
AlphaFold DB A0A330D345

References