152006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 39807..40450 Replicon plasmid unnamed2
Accession NZ_CP050011
Organism Citrobacter sp. Y3

Toxin (Protein)


Gene name vagD Uniprot ID A0A5J6WAL0
Locus tag HAP28_RS25825 Protein ID WP_061549447.1
Coordinates 40034..40450 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A6P1V8K5
Locus tag HAP28_RS25820 Protein ID WP_061549448.1
Coordinates 39807..40037 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP28_RS25795 34969..35964 + 996 WP_061549453.1 hypothetical protein -
HAP28_RS25800 35968..36900 + 933 WP_166444356.1 hypothetical protein -
HAP28_RS25805 37162..38037 + 876 WP_061549451.1 hypothetical protein -
HAP28_RS25810 38101..38286 - 186 WP_061549450.1 hypothetical protein -
HAP28_RS25815 38441..38839 + 399 WP_061549449.1 hypothetical protein -
HAP28_RS25820 39807..40037 + 231 WP_061549448.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HAP28_RS25825 40034..40450 + 417 WP_061549447.1 type II toxin-antitoxin system VapC family toxin Toxin
HAP28_RS25830 40640..40966 + 327 WP_071789783.1 four-helix bundle copper-binding protein -
HAP28_RS25835 41473..41703 + 231 WP_024553479.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HAP28_RS25840 41700..42116 + 417 WP_024553480.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89705 89705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.57 Da        Isoelectric Point: 6.7049

>T152006 WP_061549447.1 NZ_CP050011:40034-40450 [Citrobacter sp. Y3]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRNHRIVVSAITYAEMRFGATGPKASPRHIELVDAFCARLDAIQPWDRA
AVDATTEIKVALRLTGTPIGPNDTAIAGHAIAVGAILVTNNTREFERVPGLVLEDWVN

Download         Length: 417 bp

>T152006 NZ_CP065918:c1122329-1122126 [Yersinia pestis EV NIIEG]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8737.83 Da        Isoelectric Point: 4.3775

>AT152006 WP_061549448.1 NZ_CP050011:39807-40037 [Citrobacter sp. Y3]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKAEPDFMAEREDVVSDEGRFDL

Download         Length: 231 bp

>AT152006 NZ_CP065918:c1122746-1122378 [Yersinia pestis EV NIIEG]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J6WAL0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8K5

References