152005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 9661..10187 Replicon plasmid unnamed2
Accession NZ_CP050011
Organism Citrobacter sp. Y3

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HAP28_RS25640 Protein ID WP_000323025.1
Coordinates 9661..9948 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HAP28_RS25645 Protein ID WP_000534858.1
Coordinates 9948..10187 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP28_RS25600 5479..5814 - 336 WP_166444336.1 hypothetical protein -
HAP28_RS25605 5857..6648 - 792 WP_166444337.1 N-6 DNA methylase -
HAP28_RS25610 6689..6835 - 147 WP_047353114.1 hypothetical protein -
HAP28_RS25615 6923..7384 - 462 WP_166444338.1 DUF1419 domain-containing protein -
HAP28_RS25620 7462..7668 - 207 WP_166444339.1 hypothetical protein -
HAP28_RS25625 7730..8044 - 315 WP_166444340.1 hypothetical protein -
HAP28_RS25630 8669..9154 + 486 WP_166444341.1 cytoplasmic protein -
HAP28_RS25635 9431..9589 - 159 WP_014063856.1 type I toxin-antitoxin system Hok family toxin -
HAP28_RS25640 9661..9948 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HAP28_RS25645 9948..10187 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HAP28_RS25650 10450..11373 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
HAP28_RS25655 11573..12145 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HAP28_RS25660 12788..14128 - 1341 WP_000589001.1 ISNCY family transposase -
HAP28_RS25665 14438..14632 - 195 WP_166444367.1 hypothetical protein -
HAP28_RS25670 14674..14904 - 231 WP_166444342.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89705 89705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T152005 WP_000323025.1 NZ_CP050011:c9948-9661 [Citrobacter sp. Y3]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T152005 NZ_CP065912:3029-3355 [Paracoccus marcusii]
GTGAAGCGCGGGGATCTGGTGACGGTCGCCTTGCAGGGCGATTACGGCAAACCGCGACCGGCGCTTGTGATCCAGTCCGA
TCAGTTTCCCGGCACGGCCTCCGTTGTGGTCCTGCCGGTCACCTCGACGCTGATGGATGCGCCCTTGCTGCGCCTGACAG
TCGAACCCGACGCCGGGAACCGCCTGCGGGCCACGTCGCAAATCATGCTGGATAAGCCCATGACCGTGAAGGCCGACAAG
ATCGGCCCTGCCTTCGGGTCGCTCGATGACGTGGCCATGGTCAGCGTCAGCCGTTCTCTGGCCCTGTTTCTCGGACTGGC
AGGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT152005 WP_000534858.1 NZ_CP050011:c10187-9948 [Citrobacter sp. Y3]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT152005 NZ_CP065912:2814-3032 [Paracoccus marcusii]
ATGCCCACCCCAGTTTCCGAACGTGTCCAGAAGCGCCGCGCGGCTCTGCGGGCCGCTGGACTGCGCCCTGTCCAGATCTG
GGTGCCTGACACCCGACGCCCCGGCTTTGCCGCCGAGTGCCGCCGTCAGGCCGCTCTGGTGGCCGAAGCTGACCGGACCG
ATACCGACATGCAGGATTTCATGGATGCCGCCCTGGCGGATCTGGACGACTGGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References