Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4368897..4369551 Replicon chromosome
Accession NZ_CP050009
Organism Citrobacter sp. Y3

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag HAP28_RS21165 Protein ID WP_044254016.1
Coordinates 4368897..4369304 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag HAP28_RS21170 Protein ID WP_042322123.1
Coordinates 4369285..4369551 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP28_RS21145 4364802..4366535 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
HAP28_RS21150 4366541..4367254 - 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HAP28_RS21155 4367278..4368174 - 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
HAP28_RS21160 4368275..4368796 + 522 WP_042999366.1 flavodoxin FldB -
HAP28_RS21165 4368897..4369304 - 408 WP_044254016.1 protein YgfX Toxin
HAP28_RS21170 4369285..4369551 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
HAP28_RS21175 4369808..4370788 + 981 WP_109739477.1 tRNA-modifying protein YgfZ -
HAP28_RS21180 4370869..4371528 - 660 WP_044264418.1 hemolysin III family protein -
HAP28_RS21185 4371691..4372002 - 312 WP_042999362.1 N(4)-acetylcytidine aminohydrolase -
HAP28_RS21190 4372055..4372783 + 729 WP_109739479.1 MurR/RpiR family transcriptional regulator -
HAP28_RS21195 4372902..4374335 + 1434 WP_109739480.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T152001 WP_044254016.1 NZ_CP050009:c4369304-4368897 [Citrobacter sp. Y3]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T152001 NZ_CP065902:8818-9066 [Paracoccus marcusii]
ATGTTGATGATCACCTGGGACGCGCCGAAGCGGCAGACCAACCTTGCCAAGCACGGCCTGGATTTTGCCGATCTCGACGA
GGCGTTTTTTCTGGCCTCGGTGGTGGTCCCGGCAAAGGCGGGCCGGCACATGGCGATCGGGCGTCTCGCGGATGGCACCG
TGGCGGTGGTCTTCGCGGCCTTGGGCACCCAGGGGGTGTCGGTGATCTCGATGCGCCCCGCCAGCGCCAGGGAACGGAGC
CTGCTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT152001 WP_042322123.1 NZ_CP050009:c4369551-4369285 [Citrobacter sp. Y3]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT152001 NZ_CP065902:9063-9353 [Paracoccus marcusii]
ATGAGCAAGACCCATCTGACCGAAGACCAGATCCAGCGGATGATCGCCAGCGATCCGGACGCCCCTGAAGCCACAGCGGC
GCAACTCGTCCAGGCCCGGCCCTTCACAGAGGCCTTCCCGGCCCTGTCCGATGCCATGCACAGGAACATGGGCGGACGGC
CCAAGGTCGAAAACCCCAAGGTTGCCGTCTCGCTGCGCCTCGATCAGGACGTGGTGGCCCGGTTCAAGTCCAGCGGTCCC
GGCTGGCAGACCCGGATGAACCGCGCCCTGCGAGAGGCCGCAGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References