Detailed information of TA system TA151992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3074824..3075725
• Replicon: chromosome
• Accession: NZ_CP050009
• Organism: Citrobacter sp. Y3

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A837LJP8
• Locus tag: HAP28_RS14825
• Protein ID: WP_007372300.1
• Coordinates: 3074824..3075282 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HAP28_RS14830
• Protein ID: WP_008786588.1
• Coordinates: 3075279..3075725 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP28_RS14780	3070550..3070792	+	243	WP_007372291.1	hypothetical protein	-
HAP28_RS14785	3070803..3071201	+	399	WP_007372292.1	hypothetical protein	-
HAP28_RS14790	3071285..3071611	+	327	WP_007372293.1	hypothetical protein	-
HAP28_RS14795	3071974..3072312	-	339	WP_007372294.1	hypothetical protein	-
HAP28_RS14800	3072550..3072993	+	444	WP_007372295.1	hypothetical protein	-
HAP28_RS14805	3073112..3073453	+	342	WP_007372296.1	hypothetical protein	-
HAP28_RS14810	3073612..3074166	+	555	WP_007372297.1	hypothetical protein	-
HAP28_RS14815	3074216..3074482	+	267	WP_007372298.1	hypothetical protein	-
HAP28_RS14820	3074550..3074780	-	231	WP_166444225.1	hypothetical protein	-
HAP28_RS14825	3074824..3075282	-	459	WP_007372300.1	RES family NAD+ phosphorylase	Toxin
HAP28_RS14830	3075279..3075725	-	447	WP_008786588.1	DUF2384 domain-containing protein	Antitoxin
HAP28_RS14835	3075874..3076191	+	318	WP_007372302.1	hypothetical protein	-
HAP28_RS14840	3076233..3077075	+	843	WP_007372303.1	hypothetical protein	-
HAP28_RS14845	3077047..3077325	+	279	WP_007372304.1	hypothetical protein	-
HAP28_RS14850	3077385..3077828	+	444	WP_007372305.1	hypothetical protein	-
HAP28_RS14855	3078115..3078279	+	165	WP_007372306.1	hypothetical protein	-
HAP28_RS14860	3078690..3079918	+	1229	WP_110129298.1	IS3 family transposase	-
HAP28_RS14865	3079931..3080521	+	591	Protein_2925	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16975.40 Da
• Isoelectric Point: 4.5730

>T151992 WP_007372300.1 NZ_CP050009:c3075282-3074824 [Citrobacter sp. Y3]
VILYRLTKTRYLMTAWSGLGAKEAGGRWNSVGTAMVYLSETASLTMLETLVHIHAPQLLDDFTLLSLDVPDDQIQTFDMS
RLPDNWASEDAPAELALYGDNWAESGSSIALRIPSALSPVEFNYLLNPAHPELFDLMATVKKIPFRFDSRLK

Nucleotide

• Length: 459 bp

>T151992 NZ_CP065867:1902318-1902905 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16689.02 Da
• Isoelectric Point: 6.9812

>AT151992 WP_008786588.1 NZ_CP050009:c3075725-3075279 [Citrobacter sp. Y3]
MTMKVFSPDVTKTNQHCLWQVAGLDNDGIALMDKINHGLDGTVAKHISEWANITPSELRKMSGIPNTTFNRSIKDRFTAD
QSERLVRIIRVIERAVELFEGDKEAAHKWLNEANRGLSWKSPAELVSSETGALEVMRLITRIEHGVYS

Nucleotide

• Length: 447 bp

>AT151992 NZ_CP065867:1902972-1903826 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Structures

Toxin

• AlphaFold DB: A0A837LJP8