Detailed information of TA system TA151989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2082530..2083349
• Replicon: chromosome
• Accession: NZ_CP050009
• Organism: Citrobacter sp. Y3

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A3S5G4N2
• Locus tag: HAP28_RS09770
• Protein ID: WP_043001077.1
• Coordinates: 2082530..2082787 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HAP28_RS09775
• Protein ID: WP_044258114.1
• Coordinates: 2082798..2083349 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP28_RS09745	2078335..2079240	-	906	WP_043001082.1	dihydrodipicolinate synthase family protein	-
HAP28_RS09750	2079245..2080033	-	789	WP_043001081.1	IclR family transcriptional regulator	-
HAP28_RS09755	2080269..2081060	+	792	WP_109740146.1	PhzF family phenazine biosynthesis protein	-
HAP28_RS09760	2081542..2081934	+	393	WP_044258118.1	VOC family protein	-
HAP28_RS09765	2081944..2082150	+	207	WP_044258115.1	tryptophan synthase subunit alpha	-
HAP28_RS09770	2082530..2082787	+	258	WP_043001077.1	YjhX family toxin	Toxin
HAP28_RS09775	2082798..2083349	+	552	WP_044258114.1	N-acetyltransferase	Antitoxin
HAP28_RS09780	2083401..2084147	+	747	WP_061070267.1	class I SAM-dependent methyltransferase	-
HAP28_RS09785	2084824..2085408	+	585	WP_044264020.1	hypothetical protein	-
HAP28_RS09790	2085718..2086842	-	1125	WP_109740148.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.00 Da
• Isoelectric Point: 11.1381

>T151989 WP_043001077.1 NZ_CP050009:2082530-2082787 [Citrobacter sp. Y3]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTAVECYSREGLLLADCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T151989 NZ_CP065867:c142816-142535 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20365.25 Da
• Isoelectric Point: 6.0668

>AT151989 WP_044258114.1 NZ_CP050009:2082798-2083349 [Citrobacter sp. Y3]
MTTRNFTIHITDESDTNDIREVETRAFGYSKEACLVASLLEDDTARPTLSLLARQEGNAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGRGVGGLLIRTGIEHLRSMGCQCVFVLGHATYYPRHGFEPCAGDKGFPAPYPIAEEHKACWMMQSLSA
QPFDRAGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT151989 NZ_CP065867:c143040-142813 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAAGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• AlphaFold DB: A0A3S5G4N2