Detailed information of TA system TA151987

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 760584..761338
• Replicon: chromosome
• Accession: NZ_CP050009
• Organism: Citrobacter sp. Y3

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A6L5EGB6
• Locus tag: HAP28_RS03695
• Protein ID: WP_032669201.1
• Coordinates: 760961..761338 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HAP28_RS03690
• Protein ID: WP_074143921.1
• Coordinates: 760584..760910 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP28_RS03645	755812..756525	+	714	WP_032669194.1	WYL domain-containing protein	-
HAP28_RS03650	756522..757157	+	636	WP_020837117.1	hypothetical protein	-
HAP28_RS03655	757196..757651	+	456	WP_000754598.1	hypothetical protein	-
HAP28_RS03660	757648..758097	+	450	WP_032669197.1	hypothetical protein	-
HAP28_RS03665	758169..758400	+	232	Protein_718	DUF905 domain-containing protein	-
HAP28_RS03670	758499..759320	+	822	WP_032669198.1	DUF945 domain-containing protein	-
HAP28_RS03675	759351..759794	+	444	WP_032669199.1	antirestriction protein	-
HAP28_RS03680	759806..760285	+	480	WP_032669200.1	DNA repair protein RadC	-
HAP28_RS03685	760306..760527	+	222	WP_023567997.1	DUF987 domain-containing protein	-
HAP28_RS03690	760584..760910	+	327	WP_074143921.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HAP28_RS03695	760961..761338	+	378	WP_032669201.1	TA system toxin CbtA family protein	Toxin
HAP28_RS03700	761335..761826	+	492	WP_032672023.1	hypothetical protein	-
HAP28_RS03705	761856..762059	+	204	WP_032669203.1	DUF957 domain-containing protein	-
HAP28_RS03710	762123..762971	+	849	WP_032669204.1	DUF4942 domain-containing protein	-
HAP28_RS03720	763275..763781	+	507	WP_109739821.1	G/U mismatch-specific DNA glycosylase	-
HAP28_RS03725	763828..765672	-	1845	WP_042998197.1	RNA polymerase sigma factor RpoD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14157.93 Da
• Isoelectric Point: 6.2236

>T151987 WP_032669201.1 NZ_CP050009:760961-761338 [Citrobacter sp. Y3]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLSSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T151987 NZ_CP065866:c4483123-4482368 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATGCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11953.71 Da
• Isoelectric Point: 6.8397

>AT151987 WP_074143921.1 NZ_CP050009:760584-760910 [Citrobacter sp. Y3]
ITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA

Nucleotide

• Length: 327 bp

>AT151987 NZ_CP065866:c4483626-4483258 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCACCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: A0A6L5EGB6