Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 79263..79945 Replicon chromosome
Accession NZ_CP050009
Organism Citrobacter sp. Y3

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HAP28_RS00370 Protein ID WP_166444176.1
Coordinates 79263..79604 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HAP28_RS00375 Protein ID WP_108168484.1
Coordinates 79625..79945 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP28_RS00345 74684..75514 + 831 WP_044328463.1 AraC family transcriptional regulator -
HAP28_RS00350 75884..76096 + 213 WP_044263563.1 DUF1471 domain-containing protein -
HAP28_RS00355 76115..77212 + 1098 WP_109739709.1 alkene reductase -
HAP28_RS00360 77383..77874 + 492 WP_044254500.1 GNAT family N-acetyltransferase -
HAP28_RS00365 78316..79149 - 834 WP_099530882.1 DUF4942 domain-containing protein -
HAP28_RS00370 79263..79604 - 342 WP_166444176.1 TA system toxin CbtA family protein Toxin
HAP28_RS00375 79625..79945 - 321 WP_108168484.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HAP28_RS00380 79964..80185 - 222 WP_108168485.1 DUF987 domain-containing protein -
HAP28_RS00385 80195..80671 - 477 WP_108168486.1 RadC family protein -
HAP28_RS00390 80687..81145 - 459 WP_108168487.1 antirestriction protein -
HAP28_RS00395 81226..81462 - 237 WP_108168488.1 DUF905 domain-containing protein -
HAP28_RS00400 81540..81950 - 411 WP_043082399.1 hypothetical protein -
HAP28_RS00405 82036..82650 - 615 WP_108168489.1 hypothetical protein -
HAP28_RS00410 82647..83351 - 705 WP_108168490.1 WYL domain-containing protein -
HAP28_RS00415 83552..84385 - 834 WP_108168491.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12926.86 Da        Isoelectric Point: 8.4941

>T151986 WP_166444176.1 NZ_CP050009:c79604-79263 [Citrobacter sp. Y3]
MKPQPATTSRAAELYLSPVAVWQMLLTRLLVQHYGLTLNDTPFSDETVIQEHIDAGIMLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNAVR

Download         Length: 342 bp

>T151986 NZ_CP065866:3555568-3556146 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12027.71 Da        Isoelectric Point: 6.9370

>AT151986 WP_108168484.1 NZ_CP050009:c79945-79625 [Citrobacter sp. Y3]
MRSNITWGLQRDITPCMGARLVQEGNRLHYLADRASITGKFSDDECLKLDVVFPHFISRIESMLTTGELNPRHAHCITIY
HNGFTCEADTLGSCAYVYVVVYSTQR

Download         Length: 321 bp

>AT151986 NZ_CP065866:3554925-3555479 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References