Detailed information of TA system TA151986

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 79263..79945
• Replicon: chromosome
• Accession: NZ_CP050009
• Organism: Citrobacter sp. Y3

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HAP28_RS00370
• Protein ID: WP_166444176.1
• Coordinates: 79263..79604 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HAP28_RS00375
• Protein ID: WP_108168484.1
• Coordinates: 79625..79945 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP28_RS00345	74684..75514	+	831	WP_044328463.1	AraC family transcriptional regulator	-
HAP28_RS00350	75884..76096	+	213	WP_044263563.1	DUF1471 domain-containing protein	-
HAP28_RS00355	76115..77212	+	1098	WP_109739709.1	alkene reductase	-
HAP28_RS00360	77383..77874	+	492	WP_044254500.1	GNAT family N-acetyltransferase	-
HAP28_RS00365	78316..79149	-	834	WP_099530882.1	DUF4942 domain-containing protein	-
HAP28_RS00370	79263..79604	-	342	WP_166444176.1	TA system toxin CbtA family protein	Toxin
HAP28_RS00375	79625..79945	-	321	WP_108168484.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HAP28_RS00380	79964..80185	-	222	WP_108168485.1	DUF987 domain-containing protein	-
HAP28_RS00385	80195..80671	-	477	WP_108168486.1	RadC family protein	-
HAP28_RS00390	80687..81145	-	459	WP_108168487.1	antirestriction protein	-
HAP28_RS00395	81226..81462	-	237	WP_108168488.1	DUF905 domain-containing protein	-
HAP28_RS00400	81540..81950	-	411	WP_043082399.1	hypothetical protein	-
HAP28_RS00405	82036..82650	-	615	WP_108168489.1	hypothetical protein	-
HAP28_RS00410	82647..83351	-	705	WP_108168490.1	WYL domain-containing protein	-
HAP28_RS00415	83552..84385	-	834	WP_108168491.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12926.86 Da
• Isoelectric Point: 8.4941

>T151986 WP_166444176.1 NZ_CP050009:c79604-79263 [Citrobacter sp. Y3]
MKPQPATTSRAAELYLSPVAVWQMLLTRLLVQHYGLTLNDTPFSDETVIQEHIDAGIMLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNAVR

Nucleotide

• Length: 342 bp

>T151986 NZ_CP065866:3555568-3556146 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12027.71 Da
• Isoelectric Point: 6.9370

>AT151986 WP_108168484.1 NZ_CP050009:c79945-79625 [Citrobacter sp. Y3]
MRSNITWGLQRDITPCMGARLVQEGNRLHYLADRASITGKFSDDECLKLDVVFPHFISRIESMLTTGELNPRHAHCITIY
HNGFTCEADTLGSCAYVYVVVYSTQR

Nucleotide

• Length: 321 bp

>AT151986 NZ_CP065866:3554925-3555479 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA