Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2295392..2297052 Replicon chromosome
Accession NZ_CP049990
Organism Pusillimonas sp. DMV24BSW_D

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G9Q38_RS11175 Protein ID WP_158536718.1
Coordinates 2295392..2296246 (+) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag G9Q38_RS11180 Protein ID WP_166130980.1
Coordinates 2296249..2297052 (+) Length 268 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9Q38_RS11145 2290620..2290940 - 321 WP_119442645.1 hypothetical protein -
G9Q38_RS11150 2291299..2292081 + 783 WP_114421687.1 ABC transporter ATP-binding protein -
G9Q38_RS11155 2292148..2293143 + 996 WP_114421688.1 ABC transporter substrate-binding protein -
G9Q38_RS11160 2293185..2294024 + 840 WP_114421746.1 ABC transporter permease -
G9Q38_RS11165 2294075..2294818 + 744 WP_205962373.1 SDR family oxidoreductase -
G9Q38_RS11170 2294836..2295366 + 531 WP_166130978.1 cupin domain-containing protein -
G9Q38_RS11175 2295392..2296246 + 855 WP_158536718.1 alpha/beta hydrolase Toxin
G9Q38_RS11180 2296249..2297052 + 804 WP_166130980.1 IclR family transcriptional regulator Antitoxin
G9Q38_RS11185 2297085..2297876 + 792 WP_166130982.1 SDR family oxidoreductase -
G9Q38_RS11190 2297869..2299554 + 1686 WP_114421694.1 thiamine pyrophosphate-binding protein -
G9Q38_RS11195 2299568..2300383 + 816 WP_114421695.1 aspartate dehydrogenase -
G9Q38_RS11200 2300452..2301927 + 1476 WP_166130984.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-265)

Antitoxin

Transcription regulator IclR, N-terminal

(18-67)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 30518.46 Da        Isoelectric Point: 5.8237

>T151985 WP_158536718.1 NZ_CP049990:2295392-2296246 [Pusillimonas sp. DMV24BSW_D]
VTQAFPNSDTPTSSEPFFTYEIVKTGKGDIGLRRCGQGPHTVVLLHGISSGADSWRECARLLQNDMQVVAWDAPGYGHST
PLAQAQPQAVDYACQLQCLLNELGVDHCLVVGHSLGALMASGLAKQHDPRVKQFLLISPALGYGGTDKADQVRAGRFAAM
AEKGVQGIAQALPNRLLSALASEAHRQAVTANAMKLNEGGYRQAVELLCGDDIYRYADDFPQNTRVYCGDADIVTPPEQS
AEFAKRLGLPFELISQAGHASYIEQPQQIADLIQQAMSNVRGVA

Download         Length: 855 bp

>T151985 NZ_CP065866:1849236-1849823 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 268 a.a.        Molecular weight: 29516.73 Da        Isoelectric Point: 8.1351

>AT151985 WP_166130980.1 NZ_CP049990:2296249-2297052 [Pusillimonas sp. DMV24BSW_D]
MNEFGRLEAAQRYTVPGLERGLRILTAFTRREPVLSAPDLARRLSIPRSTVFRLLSTLEQLGLVERDESGRDYRLGTGAL
RLGFECLASKELTELGRPILERLRDITGCSCNLVVRDGRSVVYVARAVVQTPYANTVHLGTRLPAHATLFGRVLLRDLSF
EKLQQLYPEEQLQAATPKTPATVAQLYRLIQTDRTQDYVFDQGYFEPNISTLAVPVFGQAGKVVAALGITVSGNKHTPEN
ITELARSACEAADDLSSLLDHVAASRH

Download         Length: 804 bp

>AT151985 NZ_CP065866:1849890-1850744 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References