Detailed information of TA system TA151983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 781989..783605
• Replicon: chromosome
• Accession: NZ_CP049990
• Organism: Pusillimonas sp. DMV24BSW_D

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: G9Q38_RS03750
• Protein ID: WP_166127938.1
• Coordinates: 781989..783341 (-)
• Length: 451 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: G9Q38_RS03755
• Protein ID: WP_166127940.1
• Coordinates: 783345..783605 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9Q38_RS03730	777870..778700	+	831	WP_166127926.1	hypothetical protein	-
G9Q38_RS03735	778693..779367	+	675	WP_166127929.1	hypothetical protein	-
G9Q38_RS03740	779282..780157	+	876	WP_166127932.1	hypothetical protein	-
G9Q38_RS03745	780709..781830	-	1122	WP_166127934.1	HNH endonuclease	-
G9Q38_RS03750	781989..783341	-	1353	WP_166127938.1	type II toxin-antitoxin system HipA family toxin	Toxin
G9Q38_RS03755	783345..783605	-	261	WP_166127940.1	helix-turn-helix domain-containing protein	Antitoxin
G9Q38_RS03760	783948..784286	+	339	WP_205962356.1	hypothetical protein	-
G9Q38_RS03765	784297..784770	+	474	WP_166127942.1	DUF2214 domain-containing protein	-
G9Q38_RS03770	784806..785264	-	459	WP_166127945.1	YaiI/YqxD family protein	-
G9Q38_RS03775	785370..785984	+	615	WP_166127947.1	hypothetical protein	-
G9Q38_RS03780	786010..786489	-	480	WP_166127950.1	DUF2938 family protein	-
G9Q38_RS03785	786569..786991	+	423	WP_166127952.1	helix-turn-helix domain-containing protein	-
G9Q38_RS03790	787027..787503	+	477	WP_166127954.1	cysteine hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 451 a.a.
• Molecular weight: 50363.58 Da
• Isoelectric Point: 8.1760

>T151983 WP_166127938.1 NZ_CP049990:c783341-781989 [Pusillimonas sp. DMV24BSW_D]
MGRRSHTQTLYLWMNGAFVGTWRVRPHVGEILQYDDNWVNASQGRPLSLSLPFTPGNQPHRGDAVRAYFENLLPDSKAIR
ERVARRFQTSSTEAFALLAEIGRDCVGALQVLPNSAPPESVQEVTATPLNDAEVAQILRNTLAPASKINRDNDDVDFRIS
IAGAQEKTALSWLNNQWCLPHGATPTTHILKLPLGLVGNLKFDMNDSIENEWLCSKILHAYGVPVASTQILQFEDMKVLA
VERFDRMWWENEEGKRWLLRLPQEDMCQATGTPPHLKYESDGGPGVRTIMKLLATSRDPDRDRRTFFQAQVLFWMLRATD
GHAKNFSIFLRPGGTYELTPLYDVLSAYPVIGRGANQLSPFKAKMAMAVRSKNTHWVMRDIVRRHWLAVGKEHGIVAPDG
RGAEVVLGDMVEKTPEVVRSVRAMLPEKFPEHVANSILSGLQGAADKLAG

Nucleotide

• Length: 1353 bp

>T151983 NZ_CP065866:c141785-141504 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9331.76 Da
• Isoelectric Point: 8.8976

>AT151983 WP_166127940.1 NZ_CP049990:c783605-783345 [Pusillimonas sp. DMV24BSW_D]
MADFTIRTAEQLPVLLQAFRKQAGLTQSAVAMRLGVTQQTLSALERNAEKVSADRLLALLSILGVELVLRQGSDSSTPKP
PTDPNW

Nucleotide

• Length: 261 bp

>AT151983 NZ_CP065866:c142009-141782 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA