Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2137229..2137812 Replicon chromosome
Accession NZ_CP049989
Organism Hydrogenophaga sp. BA0156

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G9Q37_RS10160 Protein ID WP_166227083.1
Coordinates 2137229..2137483 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G9Q37_RS10165 Protein ID WP_166227084.1
Coordinates 2137480..2137812 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9Q37_RS10140 2132448..2134016 + 1569 WP_166227081.1 acyl-CoA synthetase -
G9Q37_RS10145 2134023..2135060 - 1038 WP_166231163.1 tRNA epoxyqueuosine(34) reductase QueG -
G9Q37_RS10150 2135109..2135660 + 552 WP_166231166.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
G9Q37_RS10155 2135657..2137123 + 1467 WP_166227082.1 N-acetylmuramoyl-L-alanine amidase -
G9Q37_RS10160 2137229..2137483 + 255 WP_166227083.1 type II toxin-antitoxin system HicA family toxin Toxin
G9Q37_RS10165 2137480..2137812 + 333 WP_166227084.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G9Q37_RS10170 2137812..2138045 + 234 WP_166227085.1 DUF167 domain-containing protein -
G9Q37_RS10175 2138058..2138564 - 507 WP_166227086.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
G9Q37_RS10180 2138564..2139898 - 1335 WP_166227087.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
G9Q37_RS10185 2139895..2140548 - 654 WP_166227088.1 DedA family protein -
G9Q37_RS10190 2140588..2142465 + 1878 WP_166227089.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9393.78 Da        Isoelectric Point: 10.5889

>T151979 WP_166227083.1 NZ_CP049989:2137229-2137483 [Hydrogenophaga sp. BA0156]
VKRSHERTLKLIFDHPISANLAWKDIEALLGALGADISEREGSRVAVVLFGEVRVFHRPHPSPHTDKGAVASVRRWLEQH
GVKP

Download         Length: 255 bp

>T151979 NZ_CP065865:c5042362-5041607 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGTGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12404.05 Da        Isoelectric Point: 6.9830

>AT151979 WP_166227084.1 NZ_CP049989:2137480-2137812 [Hydrogenophaga sp. BA0156]
MNLMTVDGYQARIEYDADTDLFRGEILGLNGGADFYGRNPRELRAEFRKSLSAFLEVCKERGIEPRRSYSGKFNLRIPAE
LHERLAIVAQAEGKSINTVAQEALQQRLAA

Download         Length: 333 bp

>AT151979 NZ_CP065865:c5042865-5042497 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCTTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References