Detailed information of TA system TA151978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 361576..362159
• Replicon: chromosome
• Accession: NZ_CP049989
• Organism: Hydrogenophaga sp. BA0156

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G9Q37_RS01685
• Protein ID: WP_166223627.1
• Coordinates: 361779..362159 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G9Q37_RS01680
• Protein ID: WP_166223624.1
• Coordinates: 361576..361782 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9Q37_RS01655	357440..358696	+	1257	WP_166223609.1	lipoprotein-releasing ABC transporter permease subunit	-
G9Q37_RS01660	358781..359458	+	678	WP_166223612.1	lipoprotein-releasing ABC transporter ATP-binding protein LolD	-
G9Q37_RS01665	359694..360107	+	414	WP_166223615.1	GreA/GreB family elongation factor	-
G9Q37_RS01670	360174..361013	+	840	WP_166223618.1	TatD family hydrolase	-
G9Q37_RS01675	361010..361504	+	495	WP_166223621.1	DNA-deoxyinosine glycosylase	-
G9Q37_RS01680	361576..361782	+	207	WP_166223624.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
G9Q37_RS01685	361779..362159	+	381	WP_166223627.1	VapC toxin family PIN domain ribonuclease	Toxin
G9Q37_RS01690	362172..362924	+	753	WP_166223630.1	spermidine synthase	-
G9Q37_RS01695	362932..364737	+	1806	WP_166223633.1	type II/IV secretion system protein	-
G9Q37_RS01700	364781..365734	+	954	WP_166223636.1	DMT family transporter	-
G9Q37_RS01705	365739..366536	+	798	WP_166223639.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13773.15 Da
• Isoelectric Point: 6.0641

>T151978 WP_166223627.1 NZ_CP049989:361779-362159 [Hydrogenophaga sp. BA0156]
MRVLVDTSVWIDHFRQGNTALVELVRLDLVLTHPMVIAEIACGTPPAPRGQTLSNLAMLQACNEASMGEVMAFIEREELY
GLGCGLVDLNLLASTLITPGAVLWTLDKRLADLARRFRVAHAAPLH

Nucleotide

• Length: 381 bp

>T151978 NZ_CP065865:4068693-4069271 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAAACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAGGGCGAGCAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGAACGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCAGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7515.71 Da
• Isoelectric Point: 8.5460

>AT151978 WP_166223624.1 NZ_CP049989:361576-361782 [Hydrogenophaga sp. BA0156]
MRTTVTIDDALYEKALEVADPGMDKADIIREAVKTYVRVQAAKRLVALGGSMPDMPDVPRRRTEPASK

Nucleotide

• Length: 207 bp

>AT151978 NZ_CP065865:4068050-4068604 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACAAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTAACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA