Detailed information of TA system TA151977

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3463881..3464541
• Replicon: chromosome
• Accession: NZ_CP049980
• Organism: Leclercia adecarboxylata strain 707804

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7H0FEK5
• Locus tag: G7098_RS16355
• Protein ID: WP_032613858.1
• Coordinates: 3463881..3464294 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A6G7TIV6
• Locus tag: G7098_RS16360
• Protein ID: WP_032613860.1
• Coordinates: 3464275..3464541 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7098_RS16335	3459879..3461612	-	1734	WP_130588241.1	single-stranded-DNA-specific exonuclease RecJ	-
G7098_RS16340	3461618..3462331	-	714	WP_165718321.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
G7098_RS16345	3462357..3463253	-	897	WP_032613854.1	site-specific tyrosine recombinase XerD	-
G7098_RS16350	3463355..3463876	+	522	WP_117386687.1	flavodoxin FldB	-
G7098_RS16355	3463881..3464294	-	414	WP_032613858.1	protein YgfX	Toxin
G7098_RS16360	3464275..3464541	-	267	WP_032613860.1	FAD assembly factor SdhE	Antitoxin
G7098_RS16365	3464846..3465826	+	981	WP_032613862.1	tRNA-modifying protein YgfZ	-
G7098_RS16370	3465956..3466615	-	660	WP_032613865.1	hemolysin III family protein	-
G7098_RS16375	3466781..3467092	-	312	WP_032613867.1	N(4)-acetylcytidine aminohydrolase	-
G7098_RS16380	3467145..3467876	+	732	WP_165718640.1	MurR/RpiR family transcriptional regulator	-
G7098_RS16385	3467989..3469422	+	1434	WP_165718322.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16231.98 Da
• Isoelectric Point: 10.6531

>T151977 WP_032613858.1 NZ_CP049980:c3464294-3463881 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Nucleotide

• Length: 414 bp

>T151977 NZ_CP065865:2506148-2506723 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCCTTCACGGCCGTCTATGACGCATGCGTTCTCTATCCCGCGCCGCTGCGGGACTTCTTGATGTGGCT
GGGGCTGTCCGGTCGGTTCCGAGCGCGCTGGAGCCAAACCATTCACGAGGAGTGGAAGCGCAACCTGCTGATCAATCGGT
CCGATCTCACCAGGGCGCAAGTCGACCGAACCTCTGACCTGATGGATCGTGCCATCCCCGATGGATTGGTAGAAGGGTAC
GAATCGCTCGCGGCCGGTCTGACCTTGCCAGATCCGGACGACCGCCACGTGCTGGCCGCCGCCATTCGCTGTGGGGCGAG
TGTGATCGTGACATTCAACCAGCGAGATTTCCCGAATGAGCTGCTGGCGCCCTATGGCGTCGAATCGCAGCACCCGGACG
AGTTCGTGGACAACCTCCTGGATCTGGACGCGGCTGCAGTCGTGTCGGCCGCACAGCGCCAGCGCGCCCAACTGAGGAAC
CCGACGATCGATGTCGATCGCTATCTCGATATCTTGCTGCGCCAAGGTCTGGTCCAGACCACCAAGGTGCTTGCTAGCTA
CCGCACCATCCTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10539.06 Da
• Isoelectric Point: 4.6787

>AT151977 WP_032613860.1 NZ_CP049980:c3464541-3464275 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT151977 NZ_CP065865:2505684-2506151 [Pseudomonas aeruginosa]
ATGACCGTTACTGCCCAATCCAAGATGACTTTGCCCGCCGAGGGTGAGGTAAAGGCAGCCGTGCAGGGTCAACGTGCCTT
GGCCGCCTACCTTGCGACGCAGTTTGAAACTCAGCACATCCAGATTTTCGATGACCAGAAGCAGGCGCACCAAGTCGAGC
TACCGACCTCGGCCTTGCGTTTGTTGGTGGATATCTTGGCCGAACTGGCCGACGGCAATGCTGTGAAGGTGGTGCCAGTC
CATGCGGAGCTGACGACACAAGAGGCAGCAGACCTGCTCAACGTGTCCCGTCCGCATTTCGTCAAGCTACTCGAAGATGG
GGTGTTGGCGTTTCATCGGACTGGCAAGCACCGCCGGGTGAGATTTGCCGATCTGATGCAGTACAAGGAGGCGCGTGAGC
GCGCCAGCGAGCAGGCGATGGCTGAACTCACCCAGCAGTCGCAAGAATTGGGAATGGGGTACGAATGA

Structures

Toxin

• AlphaFold DB: A0A7H0FEK5

Antitoxin

• AlphaFold DB: A0A6G7TIV6