Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3463881..3464541 Replicon chromosome
Accession NZ_CP049980
Organism Leclercia adecarboxylata strain 707804

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag G7098_RS16355 Protein ID WP_032613858.1
Coordinates 3463881..3464294 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag G7098_RS16360 Protein ID WP_032613860.1
Coordinates 3464275..3464541 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7098_RS16335 3459879..3461612 - 1734 WP_130588241.1 single-stranded-DNA-specific exonuclease RecJ -
G7098_RS16340 3461618..3462331 - 714 WP_165718321.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G7098_RS16345 3462357..3463253 - 897 WP_032613854.1 site-specific tyrosine recombinase XerD -
G7098_RS16350 3463355..3463876 + 522 WP_117386687.1 flavodoxin FldB -
G7098_RS16355 3463881..3464294 - 414 WP_032613858.1 protein YgfX Toxin
G7098_RS16360 3464275..3464541 - 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
G7098_RS16365 3464846..3465826 + 981 WP_032613862.1 tRNA-modifying protein YgfZ -
G7098_RS16370 3465956..3466615 - 660 WP_032613865.1 hemolysin III family protein -
G7098_RS16375 3466781..3467092 - 312 WP_032613867.1 N(4)-acetylcytidine aminohydrolase -
G7098_RS16380 3467145..3467876 + 732 WP_165718640.1 MurR/RpiR family transcriptional regulator -
G7098_RS16385 3467989..3469422 + 1434 WP_165718322.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T151977 WP_032613858.1 NZ_CP049980:c3464294-3463881 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T151977 NZ_CP065865:2506148-2506723 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCCTTCACGGCCGTCTATGACGCATGCGTTCTCTATCCCGCGCCGCTGCGGGACTTCTTGATGTGGCT
GGGGCTGTCCGGTCGGTTCCGAGCGCGCTGGAGCCAAACCATTCACGAGGAGTGGAAGCGCAACCTGCTGATCAATCGGT
CCGATCTCACCAGGGCGCAAGTCGACCGAACCTCTGACCTGATGGATCGTGCCATCCCCGATGGATTGGTAGAAGGGTAC
GAATCGCTCGCGGCCGGTCTGACCTTGCCAGATCCGGACGACCGCCACGTGCTGGCCGCCGCCATTCGCTGTGGGGCGAG
TGTGATCGTGACATTCAACCAGCGAGATTTCCCGAATGAGCTGCTGGCGCCCTATGGCGTCGAATCGCAGCACCCGGACG
AGTTCGTGGACAACCTCCTGGATCTGGACGCGGCTGCAGTCGTGTCGGCCGCACAGCGCCAGCGCGCCCAACTGAGGAAC
CCGACGATCGATGTCGATCGCTATCTCGATATCTTGCTGCGCCAAGGTCTGGTCCAGACCACCAAGGTGCTTGCTAGCTA
CCGCACCATCCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT151977 WP_032613860.1 NZ_CP049980:c3464541-3464275 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151977 NZ_CP065865:2505684-2506151 [Pseudomonas aeruginosa]
ATGACCGTTACTGCCCAATCCAAGATGACTTTGCCCGCCGAGGGTGAGGTAAAGGCAGCCGTGCAGGGTCAACGTGCCTT
GGCCGCCTACCTTGCGACGCAGTTTGAAACTCAGCACATCCAGATTTTCGATGACCAGAAGCAGGCGCACCAAGTCGAGC
TACCGACCTCGGCCTTGCGTTTGTTGGTGGATATCTTGGCCGAACTGGCCGACGGCAATGCTGTGAAGGTGGTGCCAGTC
CATGCGGAGCTGACGACACAAGAGGCAGCAGACCTGCTCAACGTGTCCCGTCCGCATTTCGTCAAGCTACTCGAAGATGG
GGTGTTGGCGTTTCATCGGACTGGCAAGCACCGCCGGGTGAGATTTGCCGATCTGATGCAGTACAAGGAGGCGCGTGAGC
GCGCCAGCGAGCAGGCGATGGCTGAACTCACCCAGCAGTCGCAAGAATTGGGAATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References